Publications - Neural Circuit Plasticity

  • Lithium modulates the muscarinic facilitation of synaptic plasticity and theta-gamma coupling in the hippocampal-prefrontal pathway

    02/16/2018
    Here we investigated the effects of lithium on prefrontal cortex responses under cholinergic drive. Lithium-treated rats were anesthetized with urethane and implanted with a ventricular cannula for muscarinic activation, a recording electrode in the medial prefrontal cortex (mPFC), and a stimulating electrode...
  • Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo

    04/29/2020
    Our results show that KET promotes an aberrant delta-high-gamma cross-frequency coupling in the PFC and an enhancement in HPC-PFC evoked responses. LTP induction prior to KET attenuates changes in synaptic efficiency and prevents the increase in cortical gamma amplitude comodulation.
  • Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: Reduced dopaminergic modulation and immediate gene expression in limbic circuits.

    05/12/2017
    The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity during acquisition of associative fear memories.
  • Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer's disease.

    04/11/2017
    Brain glucose metabolism is altered in sporadic Alzheimer's disease (sAD), whose pathologies are reproduced in rodents by intracerebroventricular (icv) infusion of streptozotocin (STZ) in subdiabetogenic doses.
  • Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia.

    07/06/2016
    Our findings indicated that short hypoxic preconditioning preceding SE promotes long-lasting protective effects on neuron survival and spatial memory.
  • Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy

    06/28/2016
    We used a TLE rat model generated by perforant path (PP) stimulation to understand whether synchrony between dorsal hippocampal and mPFC networks is altered shortly before a seizure episode.
  • Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism

    11/24/2015
    Autism is a neurodevelopmental disorder clinically characterized by deficits in communication, lack of social interaction and repetitive behaviors with restricted interests.
  • Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons

    05/13/2015
    Cortical GABAergic interneurons constitute an extremely diverse population of cells organized in a well-defined topology of precisely interconnected cells.
  • Behavioral and eeg effects of gabaergic manipulation of the nigro-tectal pathway in the wistar audiogenic rat (war) Strain II: An eeg wavelet analysis and retrograde neuronal tracer approach.

    03/05/2012
  • NMDA receptor blockade impairs the muscarinic conversion of sub-threshold transient depression into long-lasting LTD in the hippocampus prefrontal cortex pathway in vivo: Correlation with gamma oscillations.

    03/03/2012
    Cholinergic fibers from the brainstem and basal forebrain innervate the medial prefrontal cortex (mPFC) modulating neuronal activity and synaptic plasticity responses to hippocampal inputs.
  • Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo.

    03/02/2012
  • Psychiatric comorbidities in temporal lobe epilepsy: Possible relationships between psychotic disorders and involvement of limbic circuits.

    03/01/2012
  • Molecular Aspects of Synaptic Transmission

    01/01/1999
  • In vivo toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the rpesence of a glutamine-rich region in its intracellular domain

    01/01/2002
  • Neurovascular Coupling and Functional Neuroimaging in Epilepsy

    01/01/2009
  • Hippocampal Cell Proliferation and Epileptogenesis after Audiogenic Kindling are not Accompanied by Mossy Fiber Sprouting or Fluoro-Jade Staining

    01/01/2003
  • Distinct Modulatory Effects of Sleep on the Maintenance of Hippocampal and Prefrontal Cortex LTP

    01/01/2004
  • Neurogênese no Cérebro Adulto e na Condição Epiléptica

    01/01/2007
  • Neuroprotection Mechanisms in Epileptic Seizures: Basic aspects and clinical implications

    01/01/2007
  • Genes e Epilepsia I: Epilepsia e Alterações Genéticas

    01/01/2008
  • Genes e epilepsia II: expressão gênica diferencial

    01/01/2008
  • Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal-prefrontal cortex pathway of rats in vivo: a possible involvement of monoaminergic systems.

    01/01/2008
  • A semi-automated algorithm for studying neuronal oscillatory patterns: wavelet time-frequency and coherence analysis

    01/01/2008
  • Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation

    01/01/2009
  • Synaptic plasticity along the sleep wake cycle: Implications for epilepsy

    01/01/2009
  • Papel das Sinapses Elétricas em Crises Epilépticas

    01/01/2010