Publications - Neural Circuit Plasticity

  • Lithium modulates the muscarinic facilitation of synaptic plasticity and theta-gamma coupling in the hippocampal-prefrontal pathway

    Here we investigated the effects of lithium on prefrontal cortex responses under cholinergic drive. Lithium-treated rats were anesthetized with urethane and implanted with a ventricular cannula for muscarinic activation, a recording electrode in the medial prefrontal cortex (mPFC), and a stimulating electrode...
  • Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo

    Our results show that KET promotes an aberrant delta-high-gamma cross-frequency coupling in the PFC and an enhancement in HPC-PFC evoked responses. LTP induction prior to KET attenuates changes in synaptic efficiency and prevents the increase in cortical gamma amplitude comodulation.
  • Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: Reduced dopaminergic modulation and immediate gene expression in limbic circuits.

    The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity during acquisition of associative fear memories.
  • Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer's disease.

    Brain glucose metabolism is altered in sporadic Alzheimer's disease (sAD), whose pathologies are reproduced in rodents by intracerebroventricular (icv) infusion of streptozotocin (STZ) in subdiabetogenic doses.
  • Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia.

    Our findings indicated that short hypoxic preconditioning preceding SE promotes long-lasting protective effects on neuron survival and spatial memory.
  • Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy

    We used a TLE rat model generated by perforant path (PP) stimulation to understand whether synchrony between dorsal hippocampal and mPFC networks is altered shortly before a seizure episode.
  • Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism

    Autism is a neurodevelopmental disorder clinically characterized by deficits in communication, lack of social interaction and repetitive behaviors with restricted interests.
  • Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons

    Cortical GABAergic interneurons constitute an extremely diverse population of cells organized in a well-defined topology of precisely interconnected cells.
  • Behavioral and eeg effects of gabaergic manipulation of the nigro-tectal pathway in the wistar audiogenic rat (war) Strain II: An eeg wavelet analysis and retrograde neuronal tracer approach.

  • NMDA receptor blockade impairs the muscarinic conversion of sub-threshold transient depression into long-lasting LTD in the hippocampus prefrontal cortex pathway in vivo: Correlation with gamma oscillations.

    Cholinergic fibers from the brainstem and basal forebrain innervate the medial prefrontal cortex (mPFC) modulating neuronal activity and synaptic plasticity responses to hippocampal inputs.
  • Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo.

  • Psychiatric comorbidities in temporal lobe epilepsy: Possible relationships between psychotic disorders and involvement of limbic circuits.

  • Molecular Aspects of Synaptic Transmission

  • In vivo toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the rpesence of a glutamine-rich region in its intracellular domain

  • Neurovascular Coupling and Functional Neuroimaging in Epilepsy

  • Hippocampal Cell Proliferation and Epileptogenesis after Audiogenic Kindling are not Accompanied by Mossy Fiber Sprouting or Fluoro-Jade Staining

  • Distinct Modulatory Effects of Sleep on the Maintenance of Hippocampal and Prefrontal Cortex LTP

  • Neurogênese no Cérebro Adulto e na Condição Epiléptica

  • Neuroprotection Mechanisms in Epileptic Seizures: Basic aspects and clinical implications

  • Genes e Epilepsia I: Epilepsia e Alterações Genéticas

  • Genes e epilepsia II: expressão gênica diferencial

  • Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal-prefrontal cortex pathway of rats in vivo: a possible involvement of monoaminergic systems.

  • A semi-automated algorithm for studying neuronal oscillatory patterns: wavelet time-frequency and coherence analysis

  • Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation

  • Synaptic plasticity along the sleep wake cycle: Implications for epilepsy

  • Papel das Sinapses Elétricas em Crises Epilépticas