Publications - Neurodynamics

  • Using cortical neuron markers to target cells in the dorsal cochlear nucleus. eNeuro

    This work shows that cortical molecular tools may be useful for manipulating the DCN especially for tinnitus studies.
  • Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency

    We found that animals treated with salicylate moved dramatically less than saline treated animals.
  • Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT

    Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect.
  • Chrna2-OLM interneurons display different membrane properties and h-current magnitude depending on dorsoventral location

    Thus, our results highlight regional differences in membrane properties between dorsal and ventral OLM cells allowing this interneuron to differently participate in the generation of hippocampal theta rhythms depending on spatial location along the dorsoventral axis of the hippocampus.
  • A Respiration-Coupled Rhythm in the Rat Hippocampus Independent of Theta and Slow Oscillations

    Hippocampal respiration rhythm in rats. This work shows that the hippocampus produces two low-frequency rhythms at nearby frequencies: one that couples to respiration and another that is coupled to the neocortex. The results support a role for brain oscillations in connecting distant brain...
  • On the photovoltaic effect in local field potential recordings

    We found that light leads to several artifacts that resemble genuine LFP features in animals with no opsin expression, such as stereotyped peaks at the power spectrum, phase shifts across different recording channels, coupling between low and high oscillation frequencies, and sharp...
  • Chronic in vivo optogenetic stimulation modulates neuronal excitability, spine morphology, and Hebbian plasticity in the mouse hippocampus

    In this study, we investigated whether chronic optogenetic stimulation of hippocampus CA1 pyramidal neurons in freely moving mice could (a) cause morphological changes reminiscent of homeostatic scaling, (b) modulate synaptic currents that might compensate for chronic excitation, and (c) lead to alterations...
  • Crosstalk between mitochondria, calcium channels and actin cytoskeleton modulates noradrenergic activity of locus coeruleus neurons

    Locus coeruleus (LC) is the name of a group of large sized neurons located at the brain stem, which provide the main source of noradrenaline to the central nervous system, virtually, innervating the whole brain. All noradrenergic signalling provided by this nucleus...
  • Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor.

    Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor.
  • OLMa2 cells bidirectionally modulate learning

    Here we set out to determine whether selective modulation of OLMa2 cells in the intermediate CA1 affects learning and memory in vivo.
  • Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion

    Our results demonstrate that altering the contribuition of a limited population within the STN is sufficiente to achieve results similar to STN lesions and high-frequecy stimulation, but with fewer side effects.
  • Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity

    These knockout mice showed impairment in spatial memory function. Electrophysiological analyses revealed a profound alteration of oscillatory activity in the CA3 region of the hippocampus.
  • Indicadores de cálcio e de voltagem codificados geneticamente na detecção de potenciais de ação e inputs sinápticos em cultura de neurônios hipocampais

  • On High-Frequency Field Oscillations (>100 Hz) and the Spectral Leakage of Spiking Activity

    Our results argue against the idea that all high-frequency LFP activity stems from spike contamination and suggest avoiding defining brain rhythms solely based on frequency range.
  • The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants.

    In summary, we report that absence of the recently discovered synaptic vesicle protein Slc10a4 results in increased sensitivity to cholinergic stimulation.
  • Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit

    Our results give new insights to the basic connection paradigms of microcircuits that lead to coordination and the formation of assemblies.
  • OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons

    Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus.
  • Medial septal dysfunction by A -induced KCNQ channel-block in glutamatergic neurons.

  • The Electrically Stimulated Cochlea: a Simulation Study of Potential Distribution and Excitation of the Spiral Ganglion

  • A model of the electrically excited human cochlear neuron. II. Influence of the three-dimensional cochlear structure on neural excitability

  • Glycinergic mIPSCs in mouse and rat brainstem auditory nuclei: modulation by ruthenium red and the role of calcium stores

  • Differences in Glycinergic mIPSCs in the Auditory Brain Stem of Normal and Congenitally Deaf Neonatal Mice

  • Reduced low-voltage activated K+ conductances and enhanced central excitability in a congenitally deaf (dn/dn) mouse

  • Continuous wavelet transform in the evaluation of stretch reflex responses from surface EMG

  • Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness

  • Non-random nature of spontaneous mIPSCs in mouse auditory brainstem neurons revealed by recurrence quantification analysis

  • Hyperpolarization-activated ( ) currents in auditory brainstem neurons of normal and congenitally deaf mice.

  • Altered sodium currents in auditory neurons of congenitally deaf mice

  • Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei

  • Activity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways

  • A novel role for MNTB neuron dendrites in regulating action potential amplitude and cell excitability during repetitive firing

  • Kv7/KCNQ Channels Control Action Potential Phasing of Pyramidal Neurons during Hippocampal Gamma Oscillations In Vitro

  • ?-Amyloid 1-42 Oligomers Impair Function of Human Embryonic Stem Cell-Derived Forebrain Cholinergic Neurons

  • A Voltage-Sensitive Dye-Based Assay for the Identification of Differentiated Neurons Derived from Embryonic Neural Stem Cell Cultures

  • Sound stimulation modulates high-threshold K+ currents in mouse auditory brainstem neurons.

  • A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons

  • Lateral superior olive function in congenital deafness

  • Modulation of dendritic synaptic processing in the lateral superior olive by hyperpolarization-activated currents

  • Strength duration relationship for intra- versus extracellular stimulation with microelectrodes