Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency
08/28/2018
We found that animals treated with salicylate moved dramatically less than saline treated animals.
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT
02/11/2020
Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect.
Chrna2-OLM interneurons display different membrane properties and h-current magnitude depending on dorsoventral location
11/19/2019
Thus, our results highlight regional differences in membrane properties between dorsal and ventral OLM cells allowing this interneuron to differently participate in the generation of hippocampal theta rhythms depending on spatial location along the dorsoventral axis of the hippocampus.
A Respiration-Coupled Rhythm in the Rat Hippocampus Independent of Theta and Slow Oscillations
05/11/2016
Hippocampal respiration rhythm in rats.
This work shows that the hippocampus produces two low-frequency rhythms at nearby frequencies: one that couples to respiration and another that is coupled to the neocortex. The results support a role for brain oscillations in connecting distant brain...
On the photovoltaic effect in local field potential recordings
01/19/2016
We found that light leads to several artifacts that resemble genuine LFP features in animals with no opsin expression, such as stereotyped peaks at the power spectrum, phase shifts across different recording channels, coupling between low and high oscillation frequencies, and sharp...
Chronic in vivo optogenetic stimulation modulates neuronal excitability, spine morphology, and Hebbian plasticity in the mouse hippocampus
03/18/2019
In this study, we investigated whether chronic optogenetic stimulation of hippocampus CA1 pyramidal neurons in freely moving mice could (a) cause morphological changes reminiscent of homeostatic scaling, (b) modulate synaptic currents that might compensate for chronic excitation, and (c) lead to alterations...
Crosstalk between mitochondria, calcium channels and actin cytoskeleton modulates noradrenergic activity of locus coeruleus neurons
03/18/2019
Locus coeruleus (LC) is the name of a group of large sized neurons located at the brain stem, which provide the main source of noradrenaline to the central nervous system, virtually, innervating the whole brain. All noradrenergic signalling provided by this nucleus...
Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor.
09/10/2018
Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor.
Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion
05/15/2014
Our results demonstrate that altering the contribuition of a limited population within the STN is sufficiente to achieve results similar to STN lesions and high-frequecy stimulation, but with fewer side effects.
Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity
05/15/2014
These knockout mice showed impairment in spatial memory function. Electrophysiological analyses revealed a profound alteration of oscillatory activity in the CA3 region of the hippocampus.
Indicadores de cálcio e de voltagem codificados geneticamente na detecção de potenciais de ação e inputs sinápticos em cultura de neurônios hipocampais
On High-Frequency Field Oscillations (>100 Hz) and the Spectral Leakage of Spiking Activity
07/31/2013
Our results argue against the idea that all high-frequency LFP activity stems from spike contamination and suggest avoiding defining brain rhythms solely based on frequency range.
The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants.
07/30/2013
In summary, we report that absence of the recently discovered synaptic vesicle protein Slc10a4 results in increased sensitivity to cholinergic stimulation.