Evidence of progenitor cell lineage rerouting in the adult mouse hippocampus after status epilepticus. Frontiers
09/22/2020
We show that 3 days after tamoxifen-mediated recombination in cDCX/EGFP adult mice, GFP+ cells in the dentate gyrus (DG) co-expresses DCX and about 6% of these cells are proliferative neuronal progenitors.
Disentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalities
11/20/2019
In rodents, status epilepticus (SE) triggered by chemoconvulsants can differently affect the proliferation and fate of adult-born dentate granule cells (DGCs). It is unknown whether abnormal neurogenesis results from intracellular signaling associated with drug-receptor interaction, paroxysmal activity, or both.
The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control
07/10/2019
This phenotype was partially dependent on GCN2, whereas the lean phenotype was independent of GCN2. Taken together, our results indicate that IMPACT contributes to GCN2-dependent and -independent mechanisms involved in the regulation of autonomic functions in response to energy availability.
Identification of hypsarrhythmia in children with microcephaly infected by zika virus
03/18/2019
We performed hypothesis tests that indicated significant differences in the groups under analysis, where the p-values were found to be extremely small.
Recording Day and Night: Advice for New Investigators in the Sleep and Memory Field
09/18/2018
The investigation of the sleep-dependent mechanisms of memory processing and consolidation is largely based on the electrophysiological recording of action potentials (spikes), local field potentials (LFPs), and muscle activity from freely behaving rodents.
Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation
07/30/2018
This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories.
Electrophysiological evidence that the retrosplenial cortex displays a strong and specific activation phased with hippocampal theta during paradoxical (REM) sleep
08/18/2017
It is widely accepted that cortical neurons are similarly more activated during waking and paradoxical sleep (PS, aka REM) than during slow wave sleep (SWS).
Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death.