Publications - Neural Networks and Epilepsy

  • Disentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalities

    11/20/2019
    In rodents, status epilepticus (SE) triggered by chemoconvulsants can differently affect the proliferation and fate of adult-born dentate granule cells (DGCs). It is unknown whether abnormal neurogenesis results from intracellular signaling associated with drug-receptor interaction, paroxysmal activity, or both.
  • The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control

    07/10/2019
    This phenotype was partially dependent on GCN2, whereas the lean phenotype was independent of GCN2. Taken together, our results indicate that IMPACT contributes to GCN2-dependent and -independent mechanisms involved in the regulation of autonomic functions in response to energy availability.
  • Identification of hypsarrhythmia in children with microcephaly infected by zika virus

    03/18/2019
    We performed hypothesis tests that indicated significant differences in the groups under analysis, where the p-values were found to be extremely small.