Publications - Hearing and neuronal activity lab

  • Using cortical neuron markers to target cells in the dorsal cochlear nucleus. eNeuro

    This work shows that cortical molecular tools may be useful for manipulating the DCN especially for tinnitus studies.
  • Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons

    Gamma motor neurons (MNs), the efferent component of the fusimotor system, regulate muscle spindle sensitivity. Muscle spindle sensory feedback is required for proprioception that includes sensing the relative position of neighboring body parts and appropriately adjust the employed strength in a movement....
  • Firing properties of Renshaw cells defined by Chrna2 are modulated by hyperpolarizing and small conductance ion currents Ih and ISK

    Renshaw cells in the spinal cord ventral horn regulate motoneuron output through recurrent inhibition. Renshaw cells can be identified in vitro using anatomical and cellular criteria; however, their functional role in locomotion remains poorly defined because of the difficulty of functionally isolating...
  • Salicylate induces anxiety-like behaviour and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency

    We found that animals treated with salicylate moved dramatically less than saline treated animals.
  • Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT

    Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect.
  • Chrna2-OLM interneurons display different membrane properties and h-current magnitude depending on dorsoventral location

    Thus, our results highlight regional differences in membrane properties between dorsal and ventral OLM cells allowing this interneuron to differently participate in the generation of hippocampal theta rhythms depending on spatial location along the dorsoventral axis of the hippocampus.
  • Synchronization by Distal Dendrite-targeting Interneurons - phenomenon, concept and reality -

  • Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit

    Here we used the selective expression of the nicotinic cholinergic receptor alpha 2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid transporter (VIAAT) in Renshaw cells.
  • Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation

    Chrna2-Martinotti cells participate in defined cortical circuits and can synchronize pyramidal cells in a frequency-dependent manner.
  • Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit.

    Synchronization among neurons is thought to arise from the interplay between excitation and inhibition; however, the connectivity rules that contribute to synchronization are still unknown.
  • Hyperpolarization-activated ( I h ) currents in auditory brainstem neurons of normal and congenitally deaf mice

  • Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness

  • Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei

  • Altered sodium currents in auditory neurons of congenitally deaf mice

  • Sound stimulation modulates high-threshold K+ currents in mouse auditory brainstem neurons.

  • Modulation of dendritic synaptic processing in the lateral superior olive by hyperpolarization-activated currents

  • OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.

    Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus.