Publicações

  • Evidence of müller glia conversion into retina ganglion cells using neurogenin2

    12/11/2018
    Degenerative retinopathies are the leading causes of irreversible visual impairment in the elderly, affecting hundreds of millions of patients. Müller glia cells (MGC), the main type of glia found in the vertebrate retina, can resume proliferation in the rodent adult injured retina...
  • Non-visual exploration of novel objects increases the levels of plasticity factors in the rat primary visual cortex

    23/10/2018
    Our results suggest that non-visual exploration induces the activation of immediate-early genes in V1 cortex, which is suggestive of cross-modal processing in this area. Besides, the increase in the number of neurons labeled with pCaKMII may signal a condition promoting synaptic...
  • Computational models of memory consolidation and long-term synaptic plasticity during sleep

    23/10/2018
    Research on the neurobiology of sleep and the mechanisms of long-term synaptic plasticity has provided data in support of various theories of how brain activity during sleep affects long-term synaptic plasticity.
  • Hormonal Correlates Of Behavioural Profiles And Coping Strategies In Captive Capuchin Monkeys (Sapajus Libidinosus)

    01/10/2018
    In this study, we tested the hypothesis that individual differences in behavioural profiles correlate to differences in stress-related behaviours and hormonal levels in captive brown capuchin monkeys (Sapajus libidinosus).
  • Recording Day and Night: Advice for New Investigators in the Sleep and Memory Field

    18/09/2018
    The investigation of the sleep-dependent mechanisms of memory processing and consolidation is largely based on the electrophysiological recording of action potentials (spikes), local field potentials (LFPs), and muscle activity from freely behaving rodents.
  • Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor.

    10/09/2018
    Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor.
  • OLMa2 cells bidirectionally modulate learning

    03/08/2018
    Here we set out to determine whether selective modulation of OLMa2 cells in the intermediate CA1 affects learning and memory in vivo.
  • Post-class naps boost declarative learning in a naturalistic school setting

    03/08/2018
    Here we assessed the effect of post-class naps on the retention of Science and History curricular contents presented by the regular class teacher to 24 students from 5th grade. Retention was repeatedly measured 3–4 days after content learning, with weekly group randomization...
  • Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation

    30/07/2018
    This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories.
  • Theta-Gamma Cross-Frequency Analyses (Hippocampus)

    23/07/2018
    We found a canonical correlation linking speech connectedness and i) functional as well as developmentally relevant structural brain markers (degree centrality from resting state functional imaging and cortical gyrification index) ii) psychometric evaluation of thought disorder iii) aspects of cognitive performance (processing...
  • Speech structure links the neural and socio-behavioural correlates of psychotic disorders

    12/07/2018
    We found a canonical correlation linking speech connectedness and i) functional as well as developmentally relevant structural brain markers (degree centrality from resting state functional imaging and cortical gyrification index) ii) psychometric evaluation of thought disorder iii) aspects of cognitive performance (processing...
  • Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

    19/06/2018
    This study brings new evidence supporting the safety and therapeutic value of ayahuasca, dosed within an appropriate setting, to help treat depression.