• Transcriptional profile of induced and primary neurons reveals new candidate genes for lineage reprogramming

    We show that the transcriptional profile of a subpopulation of lineage-reprogrammed MEFs resembles that of primary neural progenitors and neurons, indicating that the intermediate steps enacted by reprogramming factors within MEFs during the transition to iNs are similar to those observed during...
  • Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes

    We show that cerebellum (CerebAstro) and cerebral cortex astroglia (CtxAstro) generates iNs with distinctive neurochemical and morphological properties. Both astroglial populations contribute iNs to the olfactory bulb following transplantation in the postnatal and adult mouse subventricular zone.
  • Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit

    Here we used the selective expression of the nicotinic cholinergic receptor alpha 2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid transporter (VIAAT) in Renshaw cells.
  • Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: Reduced dopaminergic modulation and immediate gene expression in limbic circuits.

    The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity during acquisition of associative fear memories.
  • Selective entrainment of gamma subbands by different slow network oscillations

    Respiration-induced oscillations and the theta rhythm modulate different gamma frequencies, suggesting that the brain uses different frequency channels for transferring different types of information.
  • Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats

    Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning.
  • Thought disorder measured as random speech structure classifies negative symptoms and schizophrenia diagnosis 6 months in advance

    This analysis relies mostly on connectedness, a structural feature of speech that is anti-correlated with negative symptoms.
  • Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer's disease.

    Brain glucose metabolism is altered in sporadic Alzheimer's disease (sAD), whose pathologies are reproduced in rodents by intracerebroventricular (icv) infusion of streptozotocin (STZ) in subdiabetogenic doses.
  • Coupled variability in primary sensory areas and the hippocampus during spontaneous activity

    The cerebral cortex is an anatomically divided and functionally specialized structure. It includes distinct areas, which work on different states over time.
  • Physiology and assessment as low-hanging fruit for education overhaul

    Physiology and assessment constitute major bottlenecks of school learning among students with low socioeconomic status.
  • Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation

    Chrna2-Martinotti cells participate in defined cortical circuits and can synchronize pyramidal cells in a frequency-dependent manner.
  • Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development

    Neuronal survival and morphological maturation depends on the action of the transcription factor calcium responsive element binding protein (CREB), which regulates expression of several target genes in an activity-dependent manner.