• Criticality between Cortical States

    Here, using both new and publicly available data, we test independent signatures of criticality and show that a phase transition occurs in an intermediate value of spiking variability, in both anesthetized and freely moving animals.
  • Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth

    Genes associated with TFBS-HS were enriched in gene ontology categories related to transcriptional regulation, signaling, differentiation/development and nervous system. Furthermore, genes associated with TFBS-HS present a higher expression breadth when compared to genes in general.
  • Hippocampal functional organization: a microstructure of the place cell network encoding space

    Here, we show that in animals confined to a small part of a maze, principal cells in the CA1/CA3 subfields of the dorsal hippocampus immunoreactive (IR) for Zif268 adhere to a ‘cluster-type’ organization.
  • Crosstalk between mitochondria, calcium channels and actin cytoskeleton modulates noradrenergic activity of locus coeruleus neurons

    Locus coeruleus (LC) is the name of a group of large sized neurons located at the brain stem, which provide the main source of noradrenaline to the central nervous system, virtually, innervating the whole brain. All noradrenergic signalling provided by this nucleus...
  • Chronic in vivo optogenetic stimulation modulates neuronal excitability, spine morphology, and Hebbian plasticity in the mouse hippocampus

    In this study, we investigated whether chronic optogenetic stimulation of hippocampus CA1 pyramidal neurons in freely moving mice could (a) cause morphological changes reminiscent of homeostatic scaling, (b) modulate synaptic currents that might compensate for chronic excitation, and (c) lead to alterations...
  • Spike sorting with Gaussian mixture models

    In this study, we explored the performance of Gaussian mixture models (GMMs) in these two steps. We extracted relevant features using a combination of common techniques (e.g., principal components, wavelets) and GMM fitting parameters (e.g., Gaussian distances).
  • Characterizing complex networks using entropy-degree diagrams: unveiling changes in functional brain connectivity induced by ayahuasca

    We show that the geodesic entropy is able to differentiate functional networks of the human brain associated with two different states of consciousness in the awaking resting state: (i) the ordinary state and (ii) a state altered by ingestion of the Ayahuasca....
  • Identification of hypsarrhythmia in children with microcephaly infected by zika virus

    We performed hypothesis tests that indicated significant differences in the groups under analysis, where the p-values were found to be extremely small.
  • PKMZ inhibition disrupts reconsolidation and erases object recognition memory

    Object recognition memory (ORM) confers the ability to discriminate the familiarity of previously encountered items.
  • Computational fluid dynamic analysis of physical forces playing a role in brain organoid cultures in two different multiplex platforms

    Here we used computational fluid dynamics (CFD) to simulate two multiplex culture conditions: steering plates on an orbital shaker and the use of a previously described bioreactor.
  • REHAB FUN: an assistive technology in neurological motor disorders rehabilitation of children with cerebral palsy

    We measured attention levels, errors, and time. The REHAB FUN has been shown to be a motivating tool for patients, and through the data acquired, the specialists can direct the treatment in an individualized way so that there are greater effectiveness and...
  • Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum

    Differential co-receptor expression and immunoglobulin levels before and during immune reactions intimate a central role for humoral immunity in RR and ENL. Decreased C4 and elevated anti-M. leprae antibodies in people with new diagnosis of leprosy may be risk factors for subsequent...