• Pyk2 overexpression in postsynaptic neurons blocks amyloid beta1-42-induced synaptotoxicity in microfluidic co-cultures. Brain Communications

    Treating the cells with antibodies that target different forms of amyloid beta suggested that low molecular weight oligomers are the likely culprit.
  • Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption

    Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolidation, and suggest that generation of artificial hPAC at recall overcomes the boundary conditions of this process.
  • Structural differences between REM and non-REM dream reports assessed by graph analysis

    These results indicate that dream reports sampled after REM awakening have on average a larger connectedness compared to those sampled after N2 (i.e. words recur with a longer range), a difference which appears to be related to underlying differences in dream...
  • On the boundary conditions of avoidance memory reconsolidation: An attractor network perspective

    In the present work, by adapting the model of Osan et al. (2011) to simulate the experimental protocols of Radiske et al. (2017), we show that such boundary condition is compatible with the dynamics of an attractor network that supports synaptic...
  • Long-term potentiation prevents ketamine-induced aberrant neurophysiological dynamics in the hippocampus-prefrontal cortex pathway in vivo

    Our results show that KET promotes an aberrant delta-high-gamma cross-frequency coupling in the PFC and an enhancement in HPC-PFC evoked responses. LTP induction prior to KET attenuates changes in synaptic efficiency and prevents the increase in cortical gamma amplitude comodulation.
  • Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT

    Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect.
  • On the involvement of BDNF signaling in memory reconsolidation

    In this review, we discuss recent reports supporting the involvement of BDNF signaling in reactivation-induced memory updating.
  • Influence of BRCA1 germline mutations in the somatic mutational burden of triple-negative breast cancer

    The data presented here indicate that in the absence of BRCA1 germline mutations, a higher number of driver mutations are required for tumor development and that different defective processes are operating in the tumorigenesis of hereditary and sporadic TNBC in young women....
  • Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors

    Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well...
  • Identification and characterization of primordial germ cells in a vocal learning Neoaves species, the zebra finch

    Our findings demonstrate important differences in the PGCs of the zebra finch and advance the first stage of creating PGC-mediated germ-line transgenics of a vocal learning species.
  • Disentangling chemical and electrical effects of status epilepticus-induced dentate gyrus abnormalities

    In rodents, status epilepticus (SE) triggered by chemoconvulsants can differently affect the proliferation and fate of adult-born dentate granule cells (DGCs). It is unknown whether abnormal neurogenesis results from intracellular signaling associated with drug-receptor interaction, paroxysmal activity, or both.
  • A distinct class of bursting neurons with strong gamma synchronization and stimulus selectivity in monkey V1

    We show that in awake monkey V1, there exists a distinct cell type (››30% of neurons) that has narrow-waveform (NW) action potentials and high spontaneous discharge rates and fires in high-frequency bursts. These neurons are more stimulus selective and phase locked to...