Differential transcript usage unravels gene expression alterations in Alzheimer’s disease human brains. Aging And Mechanisms Of Disease
07/01/2021
In this work, we probed the differential expression of genes in different brain regions of healthy and AD adult subjects using data from three large transcriptomic studies: Mayo Clinic, Mount Sinai Brain Bank (MSBB), and ROSMAP.
The entropic tongue: Disorganization of natural language under LSD. Consciousness and Cognition
01/01/2021
We investigated the hypothesis that language produced under the effects of lysergic acid diethylamide (LSD) should exhibit increased entropy and reduced semantic coherence.
Spatial clustering of orientation preference in primary visual cortex of the large rodent agouti. ISCIENCE
15/12/2020
Our results argue against V1 size as a key parameter in determining the presence of periodic orientation maps. They are consistent with a phylogenetic influence on the map layout and development, potentially reflecting distinct retinal traits or interspecies differences in cortical circuitry...
Dreaming during the Covid-19 pandemic: Computational assessment of dream reports reveals mental suffering related to fear of contagion. PLoS One
30/11/2020
These results corroborate the hypothesis that pandemic dreams reflect mental suffering, fear of contagion, and important changes in daily habits that directly impact socialization.
The dream of God: how do religion and science see lucid dreaming and other conscious states during sleep? Frontiers in Psychology
07/10/2020
Teachings from religious traditions around the world offer important insights for scientific researchers today who want to understand the full range of LD phenomenology as it has emerged through history.
The history of writing reflects the effects of education on discourse structure: implications for literacy, orality, psychosis and the axial age. Trends In Neuroscience And Education
05/10/2020
The educational pathways of oral and literate traditions are structurally divergent, with a decreasing range of recurrence in the former, and an increasing range of recurrence in the latter. Education is seemingly the driving force underlying discourse maturation
Evidence of progenitor cell lineage rerouting in the adult mouse hippocampus after status epilepticus. Frontiers
22/09/2020
We show that 3 days after tamoxifen-mediated recombination in cDCX/EGFP adult mice, GFP+ cells in the dentate gyrus (DG) co-expresses DCX and about 6% of these cells are proliferative neuronal progenitors.
Pyk2 overexpression in postsynaptic neurons blocks amyloid beta1-42-induced synaptotoxicity in microfluidic co-cultures. Brain Communications
02/09/2020
Treating the cells with antibodies that target different forms of amyloid beta suggested that low molecular weight oligomers are the likely culprit.
Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption
24/08/2020
Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolidation, and suggest that generation of artificial hPAC at recall overcomes the boundary conditions of this process.