Publications - Neuro cell

  • Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum

    Differential co-receptor expression and immunoglobulin levels before and during immune reactions intimate a central role for humoral immunity in RR and ENL. Decreased C4 and elevated anti-M. leprae antibodies in people with new diagnosis of leprosy may be risk factors for subsequent...
  • Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using Sox2, Ascl1, and Neurog2

    Here, we show that the expression of the transcription factor SRY (sex determining region Y)-box 2 (Sox2), Ascl1 or Neurog2 is sufficient to lineage-convert a small fraction of human umbilical cord mesenchymal stem cells (hUCMSCs) into iNs.
  • Instructing neuronal identity during CNS development and astroglial-lineage reprogramming: Roles of NEUROG2 and ASCL1

    In this review, we discuss the contribution of the proneural genes Neurogenin2 (Neurog2) and Achaete-scute homolog 1 (Ascl1) for the specification of neuronal phenotypes in the developing neocortex, cerebellum and retina.
  • Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats

    In the present study, we evaluated the effects of a low-dose 15-day long treatment with Ab peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Ab peptides (0.5 mL/site/day; 30 pmoL solution of Ab1–40:Ab1–42 10:1) or saline...
  • Lineage Reprogramming of Astroglial Cells from Different Origins into Distinct Neuronal Subtypes

    We show that cerebellum (CerebAstro) and cerebral cortex astroglia (CtxAstro) generates iNs with distinctive neurochemical and morphological properties. Both astroglial populations contribute iNs to the olfactory bulb following transplantation in the postnatal and adult mouse subventricular zone.
  • Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

    Understanding the mechanisms that control critical biological events of neural cell populations, such as proliferation, differentiation, or cell fate decisions, will be crucial to design therapeutic strategies for many diseases affecting the nervous system.
  • Specifc Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells

    Embryonic stem cell diferentiation in specifc cell lineages is a major issue in cell biology, and particularly, in regenerative medicine. Neural stem cells (NSCs) have the potential for self-renewal and diferentiation into neurons, astrocytes and oligodendrocytes.
  • Transcriptional profile of induced and primary neurons reveals new candidate genes for lineage reprogramming

    We show that the transcriptional profile of a subpopulation of lineage-reprogrammed MEFs resembles that of primary neural progenitors and neurons, indicating that the intermediate steps enacted by reprogramming factors within MEFs during the transition to iNs are similar to those observed during...
  • Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development

    Neuronal survival and morphological maturation depends on the action of the transcription factor calcium responsive element binding protein (CREB), which regulates expression of several target genes in an activity-dependent manner.
  • Human Brain Expansion during Evolution Is Independent of Fire Control and Cooking

    What makes humans unique? This question has fascinated scientists and philosophers for centuries and it is still a matter of intense debate. Nowadays, human brain expansion during evolution has been acknowledged to explain our empowered cognitive capabilities. The drivers for such accelerated...
  • Live Imaging of Adult Neural Stem Cells in Rodents

    Adult Neural Stem Cells (NSC) in the mouse subventricular zone (SVZ) tracked by retroviral labeling during embryonic development (GFP, green) and identified by the proliferative (Ki67, blue) and astrocyte-specific marker (GFAP, red).
  • Transcriptional Changes That Characterize the Immune Reactions of Leprosy

    These data suggest a previously underrecognized role for complement in the pathogenesis of both RR and ENL, and we propose new hypotheses for reaction pathogenesis.
  • Editorial: Progenitor diversity and neural cell specification in the central nervous system

    The central nervous system (CNS) harbors an enormous diversity of neuronal and glial cell types, which can be identified according to morphological, chemical, and electrical properties.
  • Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences

    The mature cerebral cortex harbors a heterogeneous population of glutamatergic neurons, organized into a highly intricate histological architecture. Classically, this mixed population of neurons was thought to be generated sequentially from a seemingly homogenous group of progenitors under the influence...
  • Astrocyte heterogeneity in the brain: from development to disease

    In this review, we focused on astrocyte heterogeneity in terms of their morphological, protein expression and functional aspects, and debate in a historical perspective the diversity encountered in glial rogenitors and how they may reflect mature astrocyte heterogeneity.
  • Proliferative Defects and Formation of a Double Cortex in Mice Lacking Mltt4 and Cdh2 in the Dorsal Telencephalon

    Here we show that the adherens junction proteins afadin and CDH2 are critical for the control of cell proliferation in the dorsal telencephalon and for the formation of its normal laminar structure.
  • Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases astrogliogenesis

    In this work, we investigated whether SHH signaling influences the behavior of neural progenitors isolated from the dorsal telencephalon, which generate excitatory neurons and macroglial cells in vitro. We observed that SHH increases proliferation of cortical progenitors and generation of astrocytes, whereas...
  • Efeitos da sinalização Via Creb sobre a sobrevivência e diferenciação neuronal

  • Indicadores de cálcio e de voltagem codificados geneticamente na detecção de potenciais de ação e inputs sinápticos em cultura de neurônios hipocampais

  • Efeitos da eliminação de neurônios infragranulares sobre a especificação de neurônios supragranulares do córtex cerebral

  • Adult neural stem cells: plastic or restricted neuronal fates?

    "Adult brain maintains plastic neural stem cells that are capable of responding to changes in environmental cues and generating diverse neuronal types"
  • Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog Glia

    "Astrocytes (green) isolated from the cerebral cortex following traumatic injury are capable of generating neurons (red). Article published in the journal "Cell Stem Cells" describes the molecule involved in this remarkable plasticity of astrocytes after lesion"
  • A Cafeína exerce efeitos poisitivos sobre a memória tipo-episódica em ratos adultos sem influenciar a sobrevivência neuronal no giro denteado.

  • Cell therapy for stroke: use of local astrocytes.

  • Expression and Function of Ganglioside 9-O-Acetyl GD3 in Postmitotic Granule Cell Development

  • Immunoblockage of 9-O-acetyl GD3 ganglioside arrests the in vivo migration of cerebellar granule neurons

  • Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia

  • The marginal zone/layer1 as a novel niche for gliogenesis and neurogenesis in developing cerebral cortex

  • Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex

  • Late origin of glia-restricted progenitors in the developing mouse cerebral cortex

  • Does cell lineage in the developing cerebral cortex contribute to its columnar organization?

  • What determines neurogenic competence in glia?

  • Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis.

  • Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level

    This work describes an adherent culture preparation, which allows for continuous single-cell tracking of NSC behavior.
  • Continuous live imaging of adult neural stem cell division and lineage progression in vitro.

    Adult neural stem cells (NSCs) could be used to treat nervous system disorders, but does their specification require a local niche? Using adult mouse NSCs, Costa and colleagues show that progression from stem cell to neuron is cell-intrinsic and independent of the...