Claudio Queiroz

This research group is interested in understanding the link between pathological oscillations and epilepsy. They have been studying the anatomical reorganization and the changes in neuronal excitability that take place in the limbic system after a brain insult. Since the epileptic brain presents major alterations in the network excitability, why is the epileptic brain not constantly seizing? What are the cellular and network alterations that give rise to epileptiform paroxysms? In which structures do these changes take place? How easily is to foresee these alterations? Once a seizure is detected, how can one abort its progression before the behavioral manifestation? These are some of the general questions with which this group is currently involved. Their major goal is the improvement of the quality of life of people with epilepsy and to unravel the mechanisms related to seizure generation in order to open new venues for symptomatological (seizure) treatments and even for the cure of the epileptic syndromes.


Publications


  • Moura DMS, Brandão JA, Lentini C, Heinrich C, Queiroz CM, Costa MR. Evidence of progenitor cell lineage rerouting in the adult mouse hippocampus after status epilepticus. Front. Neurosci. 2020;14:571315. Doi: 10.3389/fnins.2020.571315.
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  • Moura DMS, Sales IRP, Brandão JA, Costa MR, Queiroz CM. Disentangling chemical and electrical effects of statusepilepticus-induced dentate gyrus abnormalities. Epilepsy & Behavior. 2019.
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  • Pereira CM, Filev R, Dubiela FP, Brandão BB, Queiroz CM, Ludwig RG, et al. The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control. PLOS ONE. 2019;14(6):e0217287.
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  • Sousa GC, Queiroz CM, Sousa P, Lima P, Silva AAM, Pires N, et al. Identification of hypsarrhythmia in children with microcephaly infected by zika virus. Entropy. 2019;21(3):232.
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  • Souza AC, Koike BDV, Pedrosa R, Tort ABL, Queiroz CM, Ribeiro S. Recording day and night: advice for new investigators in the sleep and memory field. In: Manahan-Vaughan D, editor. Handbook of behavioral neuroscience. Elsevier; 2019. p. 43-62.
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  • Almeida-Filho, Daniel G., Queiroz, Claudio M., Ribeiro, Sidarta. Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation. Springer. https://doi.org/10.1007/s00018-018-2886-9
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  • J. Neurosci ; 10.1523/JNEUROSCI.0026-17.2017
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  • Leite RBC, Mota-Rolim SA and Queiroz CMT (2016) Music Proficiency and Quantification of Absolute Pitch: A Large-Scale Study among Brazilian Musicians. Front. Neurosci. 10:447. doi: 10.3389/fnins.2016.00447
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  • Carvasan, C. F. ; AVANZI, R. D. T. ; Queiroz, C. M. ; XAVIER, G. F. ; Mello, L.E. ; COVOLAN, L. . m1 Acetylcholine Receptor Expression is Decreased in Hippocampal CA1 region of Aged Epileptic Animals. Aging and Disease, v. 2, p. 301-307, 2011.
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  • Bittencourt, Simone ; Dubiela, Francisco P. ; Queiroz, Claudio ; Covolan, Luciene ; Andrade, Danielle ; Lozano, Andres ; Mello, Luiz E. ; Hamani, Clement . Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. Seizure (London), v. 19, p. 242-246, 2010.
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  • Holtman, L. ; van Vliet, E.A. ; van Schaik, R. ; QUEIROZ, C.M. ; Aronica, E. ; Gorter, J.A. . Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy. Epilepsy Research, v. 84, p. 56-66, 2009.
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  • Queiroz, C. M. ; Gorter, J. A. ; Lopes da Silva, F. H. ; Wadman, W. J. . Dynamics of Evoked Local Field Potentials in the Hippocampus of Epileptic Rats With Spontaneous Seizures. Journal of Neurophysiology, v. 101, p. 1588-1597, 2008.
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  • QUEIROZ, C.M.T. ; MELLO, L. E. A. M. . Effects of herbimycin A in the pilocarpine model of temporal lobe epilepsy. Brain Research, v. 1081, p. 219-227, 2006.
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  • Guidine, P.A. ; Rezende, G.H. ; QUEIROZ, C.M.T. ; MELLO, L. E. A. M. ; Prado, V.F. ; Prado, M.A. ; Pereira, G.S. ; Moraes, M.F. . Vesicular acetylcholine transporter knock-down mice are more susceptible to pilocarpine induced status epilepticus. Neuroscience Letters, v. 436, p. 201-204, 2008.
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  • QUEIROZ, C.M. ; Mello, L.E. . Protein tyrosine kinase inhibitors modify kainic acid-induced epileptiform activity and mossy fiber sprouting but do not protect against limbic cell death. Brazilian Journal of Medical and Biological Research, v. 41, p. 403, 2008.
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  • QUEIROZ, C.M.T. ; MELLO, L. E. A. M. . Synaptic plasticity of the CA3 commissural projection in epileptic rats: an in vivo electrophysiological study. European Journal of Neuroscience, v. 25, p. 3071-3079, 2007.
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  • QUEIROZ, C.M.T. ; GALLIAN, D. M. C. . Primeiras experiências de ciência européia nos trópicos: Maurício de Nassau, Willem Pies e George Marcgrave. Videtur (USP), São Paulo, v. 20, p. 31-39, 2003.
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  • QUEIROZ, C.M.T. ; ALCANTARA, F. B. ; YAGUE, A. M. ; BIBANCOS, T. ; FRUSSA-FILHO, R. . Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice. Brazilian Journal of Medical and Biological Research, v. 35, n. 2, p. 237-242, 2002.
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  • QUEIROZ, C.M.T. ; LEITE, J. P. ; MELLO, L. E. A. M. . Modelos experimentais em epilepsias. ComCiencia, 2002.
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  • QUEIROZ, C.M.T. ; BENASSI, S. K. ; LODUCA, R. D. S. ; MELLO, L. E. A. M. . Epileptogênese e aprendizagem como fenômenos análogos: implicações práticas. Brazilian Journal of Epilepsy and Clinical Neurophysiology, v. 7, n. 1, p. 18-27, 2001.
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  • HERVAS, I. ; QUEIROZ, C.M.T. ; ADELL, A. ; ARTIGAS, F. . Role of uptake inhibition and autoreceptor activation in the control of 5-HT release in the frontal cortex and dorsal hippocampus of the rat. British Journal of Pharmacology, v. 130, n. 1, p. 160-166, 2000.
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  • RUBIN, M. A. ; ALBACH, C. A. ; BERLESE, D. B. ; BONACORSO, H. G. ; BITTENCOURT, S. R. ; QUEIROZ, C.M.T. ; MAIXNER, A. E. ;MELLO, C. F. . Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1, 5-benzodiazepine hydrogen sulfate in mice. Brazilian Journal of Medical and Biological Research, v. 33, n. 9, p. 1069-1073, 2000.
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  • FIGHERA, M. R. ; QUEIROZ, C.M.T. ; STRACKE, M. P. ; BRAUER, M. C. ; GONZALEZ-RODRIGUEZ, L. L. ; FRUSSA-FILHO, R. ; WAJNER, M. ; MELLO, C. F. . Ascorbic acid and alpha-tocopherol attenuate methylmalonic acid-induced convulsions. NeuroReport (Oxford), v. 10, n. 10, p. 2039-2043, 1999.
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  • QUEIROZ, C.M.T. ; FRUSSA-FILHO, R. . Effects of buspirone on an animal model of tardive dyskinesia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 23, n. 8, p. 1405-1418, 1999.
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  • QUEIROZ, C.M.T. ; PIOVEZAN, R. D. ; FRUSSA-FILHO, R. . Reserpine does not induce orofacial dyskinesia in spontaneously hypertensive rats. European Journal of Pharmacology, v. 356, n. 2-3, p. 105-108, 1998.
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  • BERGAMO, M. ; ABILIO, V. C. ; QUEIROZ, C.M.T. ; BARBOSA JUNIOR, H. N. ; ABDANUR, L. R. A. ; FRUSSA-FILHO, R. . Effects of age on a new animal model of tardive dyskinesia. Neurobiology of Aging, v. 18, n. 6, p. 623-629, 1997.
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  • QUEIROZ, C.M.T. ; FRUSSA-FILHO, R. . Effects of buspirone on dopaminergic supersensitivity. Life Sciences, v. 61, n. 4, p. 371-382, 1997.
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Theses

  • FARIAS, K. S.. USO DE TRANSPLANTE DE ASTRÓCITOS NA REDUÇÃO DA EPILEPSIA EXPERIMENTAL. Natal, 2018.
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  • LEITE, R. B. C. ASPECTOS COMPORTAMENTAIS E ELETROFISIOLÓGICOS DA PERCEPÇÃO DE ALTURAS SONORAS: UM ESTUDO SOBRE O “OUVIDO ABSOLUTO”. Natal, 2017.
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  • ALVES, A. M. H.. INVESTIGANDO FENÓTIPOS COMPORTAMENTAIS E ELETROFISIOLÓGICOS ASSOCIADOS AO ESTRESSE SOCIAL. Natal, 2015.
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  • Farias, Kelly Soares. Interferindo com oscilações de alta frequência no hipocampo epiléptico: consequências para as crises espontâneas / Kelly Soares Farias. – Natal, RN, 2012.
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