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4.10 – Multiple Stages of Memory Formation and Persistence

The idea that memories are not made instantly after learning but need to undergo a time-dependent, metabolically active complex consolidation process before they can be stably stored has dominated the neuroscience of learning and memory for decades.
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Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids.
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Sleep, Synaptic Plasticity, and Memory

The mechanisms underlying the intimate connection between sleep and learning are becoming increasingly clear.
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Asymmetry of the temporal code for space by hippocampal place cells

Here we show that the spike timing of place cells couples to theta phase before major increases in firing rate, anticipating the animal’s entrance into the classical, rate-based place field.
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Place and grid cells in a loop: implications for memory function and spatial coding

Based on the anatomy of the entorhinal-hippocampal circuitry, we constructed a model of place and grid cells organized in a loop to investigate their mutual influence in the establishment of their codes for space.
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Electrophysiological evidence that the retrosplenial cortex displays a strong and specific activation phased with hippocampal theta during paradoxical (REM) sleep

It is widely accepted that cortical neurons are similarly more activated during waking and paradoxical sleep (PS, aka REM) than during slow wave sleep (SWS).
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Unveiling Fast Field Oscillations through Comodulation

Comodulation analysis unveils four different types of fast LFP activity coupled to theta: two oscillations within the traditional gamma band, HFOs, and spike-leaked activity.
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Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit

Here we used the selective expression of the nicotinic cholinergic receptor alpha 2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid transporter (VIAAT) in Renshaw cells.
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Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer's disease.

Brain glucose metabolism is altered in sporadic Alzheimer's disease (sAD), whose pathologies are reproduced in rodents by intracerebroventricular (icv) infusion of streptozotocin (STZ) in subdiabetogenic doses.
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Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: Reduced dopaminergic modulation and immediate gene expression in limbic circuits.

The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity during acquisition of associative fear memories.
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Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats

Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning.
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Selective entrainment of gamma subbands by different slow network oscillations

Respiration-induced oscillations and the theta rhythm modulate different gamma frequencies, suggesting that the brain uses different frequency channels for transferring different types of information.
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