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Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using Sox2, Ascl1, and Neurog2

"Neste trabalho, Araújo e colaboradores mostram que células-tronco mesenquimais isoladas do cordão umbilical humano podem ser convertidas em neurônios induzidos (iNs) através da expressão 1 ou 2 fatores de transcrição (FTs). Na imagem, exemplo de iNs expressando (Sox2/Ascl1) ou não (Sox2/Neurog2) o transportador vesicular de GABA (vGAT), indicativo de um fenótipo GABAérgico"
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Respiration-Entrained Brain Rhythms Are Global but Often Overlooked

We summarize recent evidence showing that nasal respiration entrains oscillations at the same frequency as breathing in several regions of the rodent brain.
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Callosal Influence on Visual Receptive Fields Has an Ocular, an Orientation-and Direction Bias

One leading hypothesis on the nature of visual callosal connections (CC) is that they replicate features of intrahemispheric lateral connections. However, CC act also in the central part of the binocular visual field.
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Motion contrast in primary visual cortex: a direct comparison of single neuron and population encoding

We analyzed firing rates and phase-locking to low-gamma frequency in single cells and neuronal assemblies. Motion contrast was reflected in all measures but in semi-independent populations.
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Extracting information from the shape and spatial distribution of evoked potentials.

Over 90 years after its first recording, scalp electroencephalography (EEG) remains one ofthe most widely used techniques in human neuroscience research, in particular for the study of event-related potentials (ERPs).
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Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats

In the present study, we evaluated the effects of a low-dose 15-day long treatment with Ab peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Ab peptides (0.5 mL/site/day; 30 pmoL solution of Ab1–40:Ab1–42 10:1) or saline were bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the following 15 days) in 6-month-old Wistar male rats.
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Specifc Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells

Embryonic stem cell diferentiation in specifc cell lineages is a major issue in cell biology, and particularly, in regenerative medicine. Neural stem cells (NSCs) have the potential for self-renewal and diferentiation into neurons, astrocytes and oligodendrocytes.
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Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Understanding the mechanisms that control critical biological events of neural cell populations, such as proliferation, differentiation, or cell fate decisions, will be crucial to design therapeutic strategies for many diseases affecting the nervous system.
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The interpretation of dream meaning: Resolving ambiguity using Latent Semantic Analysis in a small corpus of text

Computer-based dreams content analysis relies on word frequencies within predefined categories in order to identify different elements in text.
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The language of geometry: Fast comprehension of geometrical primitives and rules in human adults and preschoolers

Here, we ask whether a “geometrical language” with recursive embedding also underlies the human ability to encode sequences of spatial locations.
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4.10 – Multiple Stages of Memory Formation and Persistence

The idea that memories are not made instantly after learning but need to undergo a time-dependent, metabolically active complex consolidation process before they can be stably stored has dominated the neuroscience of learning and memory for decades.
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Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids. Out of the 6,728 identified proteins, 934 were found differentially expressed in 5-MeO-DMT-treated cerebral organoids.
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Rereading the mind. Unbiased discovery of neural correlates of behavior

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