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Marcos Romualdo Costa

Marcos Romualdo Costa

Associate Professor, Brain Institute - Federal University of Rio Grande do Norte (UFRN)
Laboratory: Neuro cell
Lattes: http://lattes.cnpq.br/6118493598074445
E-mail: mrcosta@neuro.ufrn.br
Areas of interest: Cerebral cortex development, adult neurogenesis and cell-based therapies

Our laboratory is dedicated to the study of cellular and molecular mechanisms responsible for controlling proliferation and differentiation of neural progenitors during development of the cerebral cortex and adult neurogenesis. Using contemporary techniques of molecular biology to manipulate gene expression in neural progenitors or neurons, we investigate the roles of different proteins and signaling pathways in neuronal and glial specification, as well as on neuronal survival and differentiation both in the developing brain and adult cerebral cortex after ischemic or traumatic injuries such as cerebral infarction. We also use techniques of cell transplantation to study the origins of stem cells in the adult brain and to evaluate the effect of environment on the differentiation of neural progenitors. The effects of gene manipulation and cell transplantation described above are evaluated using different techniques, including electrophysiology, behavioral and microscopic analysis. Among the later, we highlight the video time-lapse microscopy, which allows the study of various cellular phenomena in real time, both in vitro (phase contrast and fluorescence microscopy) and in situ (two-photon microscopy).


Publications

Coelho, Diego M., Souza, Sandro José de, Costa, Marcos R. Transcriptional profile of induced and primary neurons reveals new candidate genes for lineage reprogramming. Jul 21st, 2017 · Score: 20.5/30 · 10.19185/matters.201704000019
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Landeira, Bruna Soares Santana, Themis Taynah da Silva Araújo, Jéssica Alves de Medeiros Tabet, Elie I. Tannous, Bakhos A. Schroeder, Timm Costa, Marcos R.. Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development. Cerebral Cortex, 2016; 1–11. doi: 10.1093/cercor/bhw387 .
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Cornélio AM, de Bittencourt-Navarrete RE, de Bittencourt Brum R, Queiroz CM and Costa MR (2016) Human Brain Expansion during Evolution Is Independent of Fire Control and Cooking. Front. Neurosci. 10:167. doi: 10.3389/fnins.2016.00167
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Ortega F and Costa MR (2016) Live Imaging of Adult Neural Stem Cells in Rodents. Front. Neurosci. 10:78. doi: 10.3389/fnins.2016.00078
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Rouaux C, Hedin-Pereira Cand, Costa MR (2015). Editorial: Progenitor diversity and neural cell specification in the central nervous system. Front. Cell. Neurosci.9:358. doi: 10.3389/fncel.2015.00358
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Kathryn M. Dupnik, Thomas B. Bair, Andressa O. Maia, Francianne M. Amorim, Marcos R. Costa, Tatjana S. L. Keesen, A Joanna G. Valverde, Maria do Carmo A. P. Queiroz, Lúcio L. Medeiros, Nelly L. de Lucena, Mary E. Wilson, Mauricio L. Nobre, Warren D. Johnson Jr, and Selma M. B. Jeronimo. Transcriptional Changes That Characterize the Immune Reactions of Leprosy. Journal of Infectious Diseases Advance Access published December 18, 2014. DOI: 10.1093/infdis/jiu612
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Calais, J. B., et al. Experience-dependent upregulation Of multiple plasticity factors in the hippocampus SCHITINE, Clarissa; NOGAROLI, Luciana; COSTA, Marcos R.; HEDIN-PEREIRA, Cecilia. Astrocyte heterogeneity in the brain: from development to disease. Frontiers in Cellular Neuroscience. v. 9, mar. 2015. doi: 10.3389/fncel.2015.00076.
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COSTA, Marcos R.; MÜLLER, Ulrich. Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences. Fontiers in Celular Neuroscience. v.8, jan. 2015. doi: 10.3389/fncel.2014.00449.
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Cristina Gil-Sanz, Bruna Landeira, Cynthia Ramos, Marcos R. Costa, and Ulrich Müller. Proliferative Defects and Formation of a Double Cortex in Mice Lacking Mltt4 and Cdh2 in the Dorsal Telencephalon. The Journal of Neuroscience, August 6, 2014 • 34(32):10475–10487 • 10475
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Araújo, Geissy L. L.; Araújo, Jessica A. M.; Schroeder, Timm; Tort, Adriano B. L.; Costa, Marcos R..Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases astrogliogenesis. Frontiers, 11 March 2014. doi: 10.3389/fncel.2014.00077
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Sequerra, Eduardo B.; Costa, M.R.; Menezes, João R. L.; Hedin-Pereira; Cecilia. Adult neural stem cells: plastic or restricted neuronal fates? Development, 2013.
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SIRKO, SWETLANA ; BEHRENDT, GWENDOLYN ; JOHANSSON, PIA ANNETTE ; TRIPATHI, PRATIBHA ; Costa, Marcos ; BEK, SARAH ; HEINRICH, CHRISTOPHE ; TIEDT, STEFFEN ; COLAK, DILEK ; DICHGANS, MARTIN ; FISCHER, ISABEL REBEKKA ; PLESNILA, NIKOLAUS ; STAUFENBIEL, MATTHIAS ; HAASS, CHRISTIAN ; SNAPYAN, MARINA ; SAGHATELYAN, ARMEN ; TSAI, LI-HUEI ; FISCHER, ANDRÉ ; GROBE, KAY ; DIMOU, LEDA ; Götz, Magdalena . Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog Glia. Cell
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CHOUCHANE, MELEK ; Costa, Marcos R. . Cell therapy for stroke: use of local astrocytes. Frontiers in Cellular Neuroscience, v. 6, p. 1-6, 2012.
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COSTA, M. R. ; Ortega, F. ; Brill, M. S. ; Beckervordersandforth, R. ; Petrone, C. ; Schroeder, T. ; Gotz, M. ; Berninger, B. . Continuous live imaging of adult neural stem cell division and lineage progression in vitro. Development (Cambridge), v. 138, p. 1057-1068, 2011.
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Ortega, Felipe ; Costa, Marcos R ; Simon-Ebert, Tatiana ; Schroeder, Timm ; Götz, Magdalena ; Berninger, Benedikt . Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level. Nature Protocols (Print), v. 6, p. 1847-1859, 2011.
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Hirschberg, A. ; Deng, S. ; Korostylev, A. ; Paldy, E. ; COSTA, M. R. ; Worzfeld, T. ; Vodrazka, P. ; Wizenmann, A. ; Gotz, M. ; Offermanns, S. ; Kuner, R. . Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis. Molecular and Cellular Biology (Print), v. 30, p. 764-780, 2010.
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Costa, Marcos Romualdo ; Götz, Magdalena ; Berninger, Benedikt . What determines neurogenic competence in glia?. Brain Research Reviews, v. 63, p. 47-59, 2010.
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Costa, Marcos ; Hedin-Pereira, C. . Does cell lineage in the developing cerebral cortex contribute to its columnar organization?. Frontiers in Neuroanatomy, p. 1, 2010.
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COSTA, M. R. ; Bucholz, O. ; Schroeder, T. ; Götz, M. . Late origin of glia-restricted progenitors in the developing mouse cerebral cortex. Cerebral Cortex (New York), v. 19, p. 135-143, 2009.
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COSTA, M. R. ; Wen, G. ; Lepier, A. ; Schroeder, T. ; Götz, M. . Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex. Development (Cambridge), v. 135, p. 11-22, 2008.

COSTA, M. R. ; Kessaris, N. ; Richardson, W.D. ; Götz, M. ; Hedin-Pereira, C. . The marginal zone/layer1 as a novel niche for gliogenesis and neurogenesis in developing cerebral cortex. The Journal of Neuroscience, v. 27, p. 11376-11388, 2007.

Berninger, B. ; COSTA, M. R. ; Koch, U. ; Schroeder, T. ; Sutor, B. ; Grothe, B. ; Götz, M. . Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia. The Journal of Neuroscience, v. 27, p. 8654-8664, 2007.

SANTIAGO, M. F. ; COSTA, M. R. ; OTERO, R. M. . Immunoblockage of 9-O-acetyl GD3 ganglioside arrests the in vivo migration of cerebellar granule neurons. The Journal of Neuroscience, v. 24, p. 474-478, 2004.

SANTIAGO, M. F. ; BERREDO-PINHO, M. ; COSTA, M. R. ; GANDRA, M. ; CAVALCANTE, L. A. ; OTERO, R. M. . Expression and Function of Ganglioside 9-O-Acetyl GD3 in Postmitotic Granule Cell Development. Mollecular and Cellular Neuroscience, v. 17, p. 488-499, 2001.

Theses

VIEIRA. Hermany Munguba. Indicadores de cálcio e de voltagem codificados geneticamente na detecção de potenciais de ação e inputs sinápticos em cultura de neurônios hipocampais / Hermany Munguba Vieira. - Natal, 2013.
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Macêdo, Priscila Tavares. A cafeína exerce efeitos positivos sobre a memória tipo episódica em ratos adultos sem influenciar a sobrevivência neural no giro dentado / Priscila Tavares Macêdo. - Natal, 2012.
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LANDEIRA, Bruna soares. Efeitos da eliminação de neurônios infragranulares sobre a especificação de neurônios supragranulares do córtex cerebral / Bruna soares Landeira. - Natal, 2012.
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Santana, Themis Taynah da Silva. Efeitos da sinalização Via Creb sobre a sobrevivência e diferenciação neuronal / Themis Taynah da Silva Santana. - Natal, 2012.
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