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Rodrigo Neves Romcy Pereira

Rodrigo Neves Romcy Pereira

Associate Professor, Brain Institute - Federal University of Rio Grande do Norte (UFRN)
Laboratory: Neural Circuit Plasticity
Lattes: http://lattes.cnpq.br/9209418339421588
E-mail: rnrpereira@neuro.ufrn.br
Areas of interest: Modelos Animais de Epilepsia e Transtornos Psiquiátricos, Plasticidade Neural, Controle da Expressão Gênica, Proteômica.

Our laboratory investigates the function and mechanisms of synaptic plasticity in cortico-limbic circuits required for the coordination of cognitive, emotional and social behaviors. Neurons located in the prefrontal cortex, ventral hippocampus, thalamus and basal forebrain make up networks involved to accomplish these behaviors. Evidence indicates that dysfunctions in these circuits underlie the appearance of abnormal behaviors observed in neurological and psychiatric disorders such as epilepsy and autism. Our lab is particularly interested in understanding how oscillatory coupling between the hipocampus and prefrontal cortex correlates to synaptic plasticity mechanisms such as LTP and LTD and how they are modulated by the local cortical GABAergic neurons. Additional focus of our lab is to investigate (1) how epileptic circuits increase the vulnerability of individuals to develop psychiatric symptoms and (2) which are the mechanisms by which neural networks in autism are affected. In order to address these questions, we use electrophysiological recordings in animal models of epilepsy and autism and evaluate neuronal activity in cortical and subcortical areas such as the prefrontal cortex, hippocampus, amygdala and thalamus. We analyze oscillations between different brain areas and correlate local field potentials, multi-unit activity and synaptic plasticity changes. Others strategies being currently undertaken in the lab include LFP-coupled ultrasound vocalization recordings, exomic sequencing and gene expression analysis using RNAseq and implementation of closed-loop electrophysiology.


Publications

DO VAL-DA SILVA RA, PEIXOTO-SANTO JE, SCANDIUZZI RC, BALISTA PA, BASSI M, GLASS ML, ROMCY-PEREIRA RN, GALVIS-ALONSO OY, LEITE JP. Decreased neuron loss and memory dysfunction in pilocarpine-treated rats pre-exposed to hypoxia. Neuroscience, 10.1016/j.neuroscience.2016.06.047, 2016.
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BROGGINI, AS; ESTEVES, IM; ROMCY-PEREIRA, RN; LEITE, JP; LEÃO, RN . Pre-ictal increase in theta synchrony between the hippocampus and prefrontal cortex in a rat model of temporal lobe epilepsy. Experimental Neurology, v. 16, p. 30050-30054, 2016.
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Anomal RF, de Villers-Sidani E, Brandão JA, Diniz R, Costa MR and Romcy-Pereira RN. Impaired Processing in the Primary Auditory Cortex of an Animal Model of Autism. Front. Syst. Neurosci., doi: 10.3389/fnsys.2015.00158.
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BRANDÃO JA and ROMCY-PEREIRA RN (2015)Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons. Front.Cell.Neurosci. 9:149. doi:10.3389/fncel.2015.00149
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ROSSETTI, F. ; RODRIGUES, M. C. ; MARRONI, S. S. ; FERNANDES, A. ; FORESTI, M. L. ; ROMCY-PEREIRA, Rodrigo Neves ; ARAUJO, D. B. ; GARCIA-CAIRASCO, N. . Behavioral and eeg effects of gabaergic manipulation of the nigro-tectal pathway in the wistar audiogenic rat (war) Strain II: An eeg wavelet analysis and retrograde neuronal tracer approach. Epilepsy & Behavior (Print), v. 24, p. 391-398, 2012.
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LOPES-AGUIAR, C. ; BUENO-JUNIOR, L. ; RUGGIERO, R. N. ; ROMCY-PEREIRA, Rodrigo Neves ; LEITE, J. P. . NMDA receptor blockade impairs the muscarinic conversion of sub-threshold transient depression into long-lasting LTD in the hippocampus prefrontal cortex pathway in vivo: Correlation with gamma oscillations. Neuropharmacology, v. 65, p. 143-155, 2012.
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BUENO JUNIOR, L. S. ; LOPES-AGUIAR, C. ; RUGGIERO, R. N. ; ROMCY-PEREIRA, Rodrigo Neves ; Leite, João P. . Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo. Plos One, v. 7, p. 1-11, 2012.
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KANDRATAVICIUS, L. ; LOPES-AGUIAR, C. ; BUENO-JUNIOR, L. ; ROMCY-PEREIRA, Rodrigo Neves ; HALLAK, J. E. C. ; LEITE, J. P. . Psychiatric comorbidities in temporal lobe epilepsy: Possible relationships between psychotic disorders and involvement of limbic circuits. Revista Brasileira de Psiquiatria (São Paulo. 1999. Impresso), v. 34, p. 454-466, 2012.
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DO VAL, R. ; BACHIEGA, G. ; ZANETTI, A. C. ; ROMCY-PEREIRA, Rodrigo Neves ; VELASCO, T. R. ; LEITE, J. P. . Papel das Sinapses Elétricas em Crises Epilépticas. Journal of Epilepsy and Clinical Neurophysiology (Impresso), v. 16, p. 149-156, 2010.
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BECKER JUNIOR, V. ; WICHERT-ANA, L. ; SILVA, R.P.L.S. ; ABUD, D. G. ; ESCORSI-ROSSET, S. ; ROMCY-PEREIRA, Rodrigo Neves ;LEITE, J. P. . Neurovascular Coupling and Functional Neuroimaging in Epilepsy. Journal of Epilepsy and Clinical Neurophysiology (Impresso), v. 15, p. 30-36, 2009.
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ROMCYPEREIRA, R ; LEITE, J ; GARCIACAIRASCO, N . Synaptic plasticity along the sleep wake cycle: Implications for epilepsy. Epilepsy & Behavior (Print), v. 14, p. 47-53, 2009.
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ROMCY-PEREIRA, Rodrigo N. ; ERRAJI-BENCHEKROUN, Loubna ; SMYRNIOTOPOULOS, Peggy ; OGAWA, Sonoko ; MELLO, Claudio V. ; SIBILLE, Etienne ; PAVLIDES, Constantine . Sleep-dependent gene expression in the hippocampus and prefrontal cortex following long-term potentiation. Physiology & Behavior, v. 98, p. 44-52, 2009.
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ROMCY-PEREIRA, Rodrigo N. ; GITAI, Daniel L. G. ; GITAI, Lívia L. G. ; LEITE, João P. ; GARCIA-CAIRASCO, Norberto ; PAÇO--LARSON, Maria Luisa . Genes e epilepsia II: expressão gênica diferencial. Revista da Associação Médica Brasileira (1992. Impresso), v. 54, p. 461-466, 2008.
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GITAI, D. G. ; ROMCY-PEREIRA, Rodrigo Neves ; GITAI, L. L. ; LEITE, J. P. ; GARCIA-CAIRASCO, N. ; PACO-LARSON, M. L. . Genes e Epilepsia I: Epilepsia e Alterações Genéticas. Revista da Associação Médica Brasileira (1992. Impresso), v. 54, p. 272-278, 2008.
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ROMCY-PEREIRA, Rodrigo Neves ; ARAUJO, D. B. ; LEITE, J. P. ; GARCIA-CAIRASCO, N. . A semi-automated algorithm for studying neuronal oscillatory patterns: wavelet time-frequency and coherence analysis. Journal of Neuroscience Methods, v. 167, p. 384-392, 2008.
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AGUIAR, C. L. ; ROMCY-PEREIRA, Rodrigo Neves ; SZAWKA, R. E. ; GALVIS-ALONSO, O. Y. ; ANSELMO-FRANCI, J. A. ;LEITE, J. P. . Muscarinic acetylcholine neurotransmission enhances the late-phase of long-term potentiation in the hippocampal-prefrontal cortex pathway of rats in vivo: a possible involvement of monoaminergic systems. Neuroscience, v. 153, p. 1309-1319, 2008.
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BACHIEGA, G. ; DO VAL, R. ; ZANETTI, A. C. ; SCANDIUZZI, R. C. ; ROMCY-PEREIRA, Rodrigo Neves ; LEITE, J. P. . Neuroprotection Mechanisms in Epileptic Seizures: Basic aspects and clinical implications. Journal of Epilepsy and Clinical Neurophysiology (Impresso), v. 13, p. 21-27, 2007.
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KANDRATAVICIUS, L. ; MONTEIRO, M. R. ; ROMCY-PEREIRA, Rodrigo Neves ; ARISI, G. M. ; GARCIA-CAIRASCO, N. ; LEITE, J. P.. Neurogênese no Cérebro Adulto e na Condição Epiléptica. Journal of Epilepsy and Clinical Neurophysiology (Impresso), v. 13, p. 119-123, 2007.
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ROMCY-PEREIRA, Rodrigo Neves ; PAVLIDES, Constantine . Distinct Modulatory Effects of Sleep on the Maintenance of Hippocampal and Prefrontal Cortex LTP. European Journal of Neuroscience (Print), v. 20, n. 12, p. 3453-3462, 2004.
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ROMCY-PEREIRA, Rodrigo Neves ; GARCIA-CAIRASCO, N. . Hippocampal Cell Proliferation and Epileptogenesis after Audiogenic Kindling are not Accompanied by Mossy Fiber Sprouting or Fluoro-Jade Staining. Neuroscience, v. 119, n. 2, p. 533-546, 2003.
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MACHADO, Ricardo C ; ROMCY-PEREIRA, Rodrigo Neves ; COSTA, Mara S ; RAMOS, Ricardo G . In vivo toxicity of a truncated version of the Drosophila Rst-IrreC protein is dependent on the presence of a glutamine-rich region in its intracellular domain. Anais da Academia Brasileira de Ciências (Impresso), v. 74, n. 2, p. 285-295, 2002.
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LOPES, A. C. P. ; ROSA, L. C. ; BELEBONI, R. O. ; ROMCY-PEREIRA, Rodrigo Neves ; VASCONCELOS, C. A. ; MOREIRA, J. E. . Molecular Aspects of Synaptic Transmission. Medicina (USP.FMRP), Ribeirão Preto, v. 32, p. 167-188, 1999.
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