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Richardson Leão

Richardson Leão

Associate Professor, Brain Institute - Federal University of Rio Grande do Norte (UFRN)
Laboratory: Neurodynamics
Lattes: http://lattes.cnpq.br/0683942077872227
E-mail: richardson.leao@neuro.ufrn.br
Areas of interest:

Our group works with circuit analysis using electrophysiology and imaging. We basically employ all the 'flavours' of patch-clamp techniques (see publications), dynamic clamp and brain modelling (from single neurons to complex networks). Regarding imaging, we work with Ca2+, Na+ and voltage imaging using dyes and we recently started to express genetically encoded voltage and Ca2+ sensors in neurons. Our group's main research topic is the study of the transfer function implemented by neurons and networks of neurons with a particular focus on the contribution of oscillations in neuronal coding in the hippocampus. Our current activities include the development of a system capable to acquire and analyse field oscillations in hippocampal slices in real time. Analysed signals are then used to modulate the firing of an artificial neuron connected to a real pyramidal cell in a closed loop configuration.


Publications

Nordenankar K, Smith-Anttila CJA, Schweizer N, Viereckel T, Birgner C, Mejia-Toiber J, Morales M, Leao RN, Walle´n-Mackenzie A (2014). Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity. Brain Struct Funct. 11 apr. DOI 10.1007/s00429-014-0778-9
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Schweizera N, Pupe S, Arvidssona E, Nordenankara K, Smith-Anttila CJA, Mahmoudid S, Andrén A, Dumase S, Rajagopalan A, Lévesqued D, Leão RN, Wallén-Mackenzie A (2014). Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion. PNAS. 1-6. http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1323499111/-/DCSupplemental.
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SCHEFFER-TEIXEIRA, R. ; BELCHIOR, H. ; LEAO, R. N. ; RIBEIRO, S. ; TORT, A. B. L. . On High-Frequency Field Oscillations (>100 Hz) and the Spectral Leakage of Spiking Activity. The Journal of Neuroscience, v. 33, p. 1535-1539, 2013.
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HILSCHER, M. M. ; Leão, Katarina E. ; LEAO, R. N. . Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit. Frontiers in Neural Circuits, v. 7, p. 120, 2013.
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ZELANO, J. ; MIKULOVIC, S. ; PATRA, K. ; KÜHNEMUND, M. ; LARHAMMAR, M. ; EMILSSON, L. ; LEAO, R. ; Kullander, K. The synaptic protein encoded by the gene Slc10A4 suppresses epileptiform activity and regulates sensitivity to cholinergic chemoconvulsants. Experimental Neurology, v. 239, p. 73-81, 2013.
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LEAO, R.N. ; MIKULOVIC, S. ; Leão, Katarina E. ; MUNGUBA, H. ; GEZELIUS, H ; Enjin A ; Patra, K ; Eriksson, A. ; LOEW, L. M. ; TORT, A. ; Kullander, K. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nature Neuroscience, v. 15, p. 1524-1530, 2012.
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Leão, Richardson N. ; Colom, Luis V. ; Borgius, Lotta ; Kiehn, Ole ; Fisahn, André . Medial septal dysfunction by A -induced KCNQ channel-block in glutamatergic neurons. Neurobiology of Aging, v. 33, p. 2046-2061, 2012.
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Rattay, F. ; Paredes, L.P. ; Leao, R.N.. Strength duration relationship for intra- versus extracellular stimulation with microelectrodes. Neuroscience, v. 1, p. 1, 2012.
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Couchman, Kiri ; Garrett, Andrew ; Deardorff, Adam S. ; Rattay, Frank ; Resatz, Susanne ; Fyffe, Robert ; Walmsley, Bruce ; Leão, Richardson N. . Lateral superior olive function in congenital deafness. Hearing Research, v. 277, p. 163-175, 2011.
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Leão, Katarina E. ; Leão, Richardson N. ; Walmsley, Bruce. Modulation of dendritic synaptic processing in the lateral superior olive by hyperpolarization-activated currents. European Journal of Neuroscience (Print), v. 33, p. 1462-1470, 2011.
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Borgius, Lotta ; Restrepo, C. Ernesto ; Leao, Richardson N. ; Saleh, Noor ; Kiehn, Ole . A transgenic mouse line for molecular genetic analysis of excitatory glutamatergic neurons. Molecular and Cellular Neurosciences (Print), v. 45, p. 245-257, 2010.
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Leão, Katarina E. ; Leão, Richardson N. ; Deardorff, Adam S. ; Garrett, Andrew ; Fyffe, Robert ; Walmsley, Bruce . Sound stimulation modulates high-threshold K+ currents in mouse auditory brainstem neurons. European Journal of Neuroscience (Print), v. 32, p. 1658-1667, 2010.
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Leão, Richardson N. ; Reis, Amilcar ; Emirandetti, Amanda ; Lewicka, Michalina ; Hermanson, Ola ; Fisahn, André ; Chin, Wei-Chun . A Voltage-Sensitive Dye-Based Assay for the Identification of Differentiated Neurons Derived from Embryonic Neural Stem Cell Cultures. Plos One, v. 5, p. e13833, 2010.
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Wicklund, Linn ; Leão, Richardson N. ; Strömberg, Anne-Marie ; Mousavi, Malahat ; Hovatta, Outi ; Nordberg, Agneta ; Marutle, Amelia ; Combs, Colin . ?-Amyloid 1-42 Oligomers Impair Function of Human Embryonic Stem Cell-Derived Forebrain Cholinergic Neurons. Plos One, v. 5, p. e15600, 2010.
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LEAO, R. N. ; Tan, H. M. ; FISAHN, A. . Kv7/KCNQ Channels Control Action Potential Phasing of Pyramidal Neurons during Hippocampal Gamma Oscillations In Vitro. The Journal of Neuroscience, v. 29, p. 13353-13364, 2009.
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Leo, Richardson N. ; Leo, Ricardo M. ; da Costa, Luciano F. ; Rock Levinson, S. ; Walmsley, Bruce . A novel role for MNTB neuron dendrites in regulating action potential amplitude and cell excitability during repetitive firing. European Journal of Neuroscience, v. 27, p. 3095-3108, 2008.
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Walmsley, B. ; Berntson, Amy ; LEAO, R. N. . Activity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways. Journal of Physiology (London), v. 572, p. 313-321, 2006.
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Leao, K. E. ; LEAO, R. N. ; Sun, H. ; Fyffe, R. E. W. ; Walmsley, B. . Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei. Journal of Physiology (London), v. 576, p. 849-864, 2006.
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Leão, Richardson N. ; Naves, Marcell M. ; Leão, Katarina E. ; Walmsley, Bruce. Altered sodium currents in auditory neurons of congenitally deaf mice. European Journal of Neuroscience, v. 24, p. 1137-1146, 2006.
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LEAO, R. N. ; Svahn, Katarina ; Berntson, Amy ; Walmsley, Bruce . Hyperpolarization-activated ( ) currents in auditory brainstem neurons of normal and congenitally deaf mice. European Journal of Neuroscience (Print), v. 22, p. 147-157, 2005.
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Leao, Richardson N. ; Leao, Fabricio N. ; Walmsley, Bruce . Non-random nature of spontaneous mIPSCs in mouse auditory brainstem neurons revealed by recurrence quantification analysis. Proceedings of the Royal Society of London. Biological Sciences, v. 272, p. 2551-2559, 2005.
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LEAO, R. N. . Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness. Journal of Physiology (London), v. 571, p. 563-578, 2005.
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LEAO, R. N. . Continuous wavelet transform in the evaluation of stretch reflex responses from surface EMG. Journal of Neuroscience Methods, v. 133, p. 115-125, 2004.
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LEAO, R. N. . Reduced low-voltage activated K+ conductances and enhanced central excitability in a congenitally deaf (dn/dn) mouse. Journal of Physiology (London), v. 559, p. 25-33, 2004.
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LEAO, R. N. . Differences in Glycinergic mIPSCs in the Auditory Brain Stem of Normal and Congenitally Deaf Neonatal Mice. Journal of Neurophysiology, v. 91, p. 1006-1012, 2003.
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Lim, R. ; OLESKEVICH, S. ; FEW, A. P. ; LEAO, R. N. . Glycinergic mIPSCs in mouse and rat brainstem auditory nuclei: modulation by ruthenium red and the role of calcium stores. Journal of Physiology (London), v. 546, p. 691-699, 2002.
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Rattay, F ; LEAO, R. N. ; FELIX, H. . A model of the electrically excited human cochlear neuron. II. Influence of the three-dimensional cochlear structure on neural excitability. Hearing Research, v. 153, p. 64-79, 2001.
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Rattay, F ; LEAO, R. N. ; LUTER, P. . The Electrically Stimulated Cochlea: a Simulation Study of Potential Distribution and Excitation of the Spiral Ganglion.. Medical & Biological Engineering & Computing, v. 37, p. 802-803, 1999.

Theses

VIEIRA. Hermany Munguba. Indicadores de cálcio e de voltagem codificados geneticamente na detecção de potenciais de ação e inputs sinápticos em cultura de neurônios hipocampais / Hermany Munguba Vieira. - Natal, 2013.
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