›  Home  ›  aboutus  ›  Marcos Romualdo Costa  
Marcos Romualdo Costa

Marcos Romualdo Costa

Associate Professor, Brain Institute - Federal University of Rio Grande do Norte (UFRN)
Laboratory: Neuro cell
Lattes: http://lattes.cnpq.br/6118493598074445
E-mail: mrcosta@neuro.ufrn.br
Areas of interest: Cerebral cortex development, adult neurogenesis and cell-based therapies

Our laboratory is dedicated to the study of cellular and molecular mechanisms responsible for controlling proliferation and differentiation of neural progenitors during development of the cerebral cortex and adult neurogenesis. Using contemporary techniques of molecular biology to manipulate gene expression in neural progenitors or neurons, we investigate the roles of different proteins and signaling pathways in neuronal and glial specification, as well as on neuronal survival and differentiation both in the developing brain and adult cerebral cortex after ischemic or traumatic injuries such as cerebral infarction. We also use techniques of cell transplantation to study the origins of stem cells in the adult brain and to evaluate the effect of environment on the differentiation of neural progenitors. The effects of gene manipulation and cell transplantation described above are evaluated using different techniques, including electrophysiology, behavioral and microscopic analysis. Among the later, we highlight the video time-lapse microscopy, which allows the study of various cellular phenomena in real time, both in vitro (phase contrast and fluorescence microscopy) and in situ (two-photon microscopy).


Publications

Landeira, Bruna Soares Santana, Themis Taynah da Silva Araújo, Jéssica Alves de Medeiros Tabet, Elie I. Tannous, Bakhos A. Schroeder, Timm Costa, Marcos R.. Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development. Cerebral Cortex, 2016; 1–11. doi: 10.1093/cercor/bhw387 .
Full Text

Cornélio AM, de Bittencourt-Navarrete RE, de Bittencourt Brum R, Queiroz CM and Costa MR (2016) Human Brain Expansion during Evolution Is Independent of Fire Control and Cooking. Front. Neurosci. 10:167. doi: 10.3389/fnins.2016.00167
Full Text

Ortega F and Costa MR (2016) Live Imaging of Adult Neural Stem Cells in Rodents. Front. Neurosci. 10:78. doi: 10.3389/fnins.2016.00078
Full Text

Rouaux C, Hedin-Pereira Cand, Costa MR (2015). Editorial: Progenitor diversity and neural cell specification in the central nervous system. Front. Cell. Neurosci.9:358. doi: 10.3389/fncel.2015.00358
Full Text

Kathryn M. Dupnik, Thomas B. Bair, Andressa O. Maia, Francianne M. Amorim, Marcos R. Costa, Tatjana S. L. Keesen, A Joanna G. Valverde, Maria do Carmo A. P. Queiroz, Lúcio L. Medeiros, Nelly L. de Lucena, Mary E. Wilson, Mauricio L. Nobre, Warren D. Johnson Jr, and Selma M. B. Jeronimo. Transcriptional Changes That Characterize the Immune Reactions of Leprosy. Journal of Infectious Diseases Advance Access published December 18, 2014. DOI: 10.1093/infdis/jiu612
Full Text

Calais, J. B., et al. Experience-dependent upregulation Of multiple plasticity factors in the hippocampus SCHITINE, Clarissa; NOGAROLI, Luciana; COSTA, Marcos R.; HEDIN-PEREIRA, Cecilia. Astrocyte heterogeneity in the brain: from development to disease. Frontiers in Cellular Neuroscience. v. 9, mar. 2015. doi: 10.3389/fncel.2015.00076.
Full Text

COSTA, Marcos R.; MÜLLER, Ulrich. Specification of excitatory neurons in the developing cerebral cortex: progenitor diversity and environmental influences. Fontiers in Celular Neuroscience. v.8, jan. 2015. doi: 10.3389/fncel.2014.00449.
Full Text

Cristina Gil-Sanz, Bruna Landeira, Cynthia Ramos, Marcos R. Costa, and Ulrich Müller. Proliferative Defects and Formation of a Double Cortex in Mice Lacking Mltt4 and Cdh2 in the Dorsal Telencephalon. The Journal of Neuroscience, August 6, 2014 • 34(32):10475–10487 • 10475
Full Text

Araújo, Geissy L. L.; Araújo, Jessica A. M.; Schroeder, Timm; Tort, Adriano B. L.; Costa, Marcos R..Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases astrogliogenesis. Frontiers, 11 March 2014. doi: 10.3389/fncel.2014.00077
Full Text

Sequerra, Eduardo B.; Costa, M.R.; Menezes, João R. L.; Hedin-Pereira; Cecilia. Adult neural stem cells: plastic or restricted neuronal fates? Development, 2013.
Full Text

SIRKO, SWETLANA ; BEHRENDT, GWENDOLYN ; JOHANSSON, PIA ANNETTE ; TRIPATHI, PRATIBHA ; Costa, Marcos ; BEK, SARAH ; HEINRICH, CHRISTOPHE ; TIEDT, STEFFEN ; COLAK, DILEK ; DICHGANS, MARTIN ; FISCHER, ISABEL REBEKKA ; PLESNILA, NIKOLAUS ; STAUFENBIEL, MATTHIAS ; HAASS, CHRISTIAN ; SNAPYAN, MARINA ; SAGHATELYAN, ARMEN ; TSAI, LI-HUEI ; FISCHER, ANDRÉ ; GROBE, KAY ; DIMOU, LEDA ; Götz, Magdalena . Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog Glia. Cell
Full Text

CHOUCHANE, MELEK ; Costa, Marcos R. . Cell therapy for stroke: use of local astrocytes. Frontiers in Cellular Neuroscience, v. 6, p. 1-6, 2012.
Full Text

COSTA, M. R. ; Ortega, F. ; Brill, M. S. ; Beckervordersandforth, R. ; Petrone, C. ; Schroeder, T. ; Gotz, M. ; Berninger, B. . Continuous live imaging of adult neural stem cell division and lineage progression in vitro. Development (Cambridge), v. 138, p. 1057-1068, 2011.
Full Text

Ortega, Felipe ; Costa, Marcos R ; Simon-Ebert, Tatiana ; Schroeder, Timm ; Götz, Magdalena ; Berninger, Benedikt . Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level. Nature Protocols (Print), v. 6, p. 1847-1859, 2011.
Full Text

Hirschberg, A. ; Deng, S. ; Korostylev, A. ; Paldy, E. ; COSTA, M. R. ; Worzfeld, T. ; Vodrazka, P. ; Wizenmann, A. ; Gotz, M. ; Offermanns, S. ; Kuner, R. . Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis. Molecular and Cellular Biology (Print), v. 30, p. 764-780, 2010.
Full Text

Costa, Marcos Romualdo ; Götz, Magdalena ; Berninger, Benedikt . What determines neurogenic competence in glia?. Brain Research Reviews, v. 63, p. 47-59, 2010.
Full Text

Costa, Marcos ; Hedin-Pereira, C. . Does cell lineage in the developing cerebral cortex contribute to its columnar organization?. Frontiers in Neuroanatomy, p. 1, 2010.
Full Text

COSTA, M. R. ; Bucholz, O. ; Schroeder, T. ; Götz, M. . Late origin of glia-restricted progenitors in the developing mouse cerebral cortex. Cerebral Cortex (New York), v. 19, p. 135-143, 2009.
Full Text

COSTA, M. R. ; Wen, G. ; Lepier, A. ; Schroeder, T. ; Götz, M. . Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex. Development (Cambridge), v. 135, p. 11-22, 2008.
Full Text

COSTA, M. R. ; Kessaris, N. ; Richardson, W.D. ; Götz, M. ; Hedin-Pereira, C. . The marginal zone/layer1 as a novel niche for gliogenesis and neurogenesis in developing cerebral cortex. The Journal of Neuroscience, v. 27, p. 11376-11388, 2007.
Full Text

Berninger, B. ; COSTA, M. R. ; Koch, U. ; Schroeder, T. ; Sutor, B. ; Grothe, B. ; Götz, M. . Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia. The Journal of Neuroscience, v. 27, p. 8654-8664, 2007.
Full Text

SANTIAGO, M. F. ; COSTA, M. R. ; OTERO, R. M. . Immunoblockage of 9-O-acetyl GD3 ganglioside arrests the in vivo migration of cerebellar granule neurons. The Journal of Neuroscience, v. 24, p. 474-478, 2004.
Full Text

SANTIAGO, M. F. ; BERREDO-PINHO, M. ; COSTA, M. R. ; GANDRA, M. ; CAVALCANTE, L. A. ; OTERO, R. M. . Expression and Function of Ganglioside 9-O-Acetyl GD3 in Postmitotic Granule Cell Development. Mollecular and Cellular Neuroscience, v. 17, p. 488-499, 2001.
Full Text

Theses

VIEIRA. Hermany Munguba. Indicadores de cálcio e de voltagem codificados geneticamente na detecção de potenciais de ação e inputs sinápticos em cultura de neurônios hipocampais / Hermany Munguba Vieira. - Natal, 2013.
Full Text [PDF]

Macêdo, Priscila Tavares. A cafeína exerce efeitos positivos sobre a memória tipo episódica em ratos adultos sem influenciar a sobrevivência neural no giro dentado / Priscila Tavares Macêdo. - Natal, 2012.
Full Text [PDF]

LANDEIRA, Bruna soares. Efeitos da eliminação de neurônios infragranulares sobre a especificação de neurônios supragranulares do córtex cerebral / Bruna soares Landeira. - Natal, 2012.
Full Text [PDF]

Santana, Themis Taynah da Silva. Efeitos da sinalização Via Creb sobre a sobrevivência e diferenciação neuronal / Themis Taynah da Silva Santana. - Natal, 2012.
Full Text [PDF]


Last entries