›  Home  ›  aboutus  ›  Emelie Katarina Svahn Leão  
Emelie Katarina Svahn Leão

Emelie Katarina Svahn Leão

Associate Professor, Brain Institute - Federal University of Rio Grande do Norte (UFRN)
Laboratory: Hearing and neuronal activity lab
Lattes: http://lattes.cnpq.br/1279823352935722
E-mail: katarina.leao@neuro.ufrn.br
Areas of interest: The pathological perception of sounds in the auditory system (in relation to tinnitus and psychosis)

Master degree in Pharmaceutical Bioscience from University of Gothenburg, Sweden, 2004. She obtained a PhD in Neuroscience at the National University of Australia, Canberra, Australia, 2008, studying plasticity in the auditory system of mice. Returning to Sweden for a postdoc at Uppsala University she took part in several projects using transgenic animals, using electrophysiology and immunohistochemistry. In 2012 she became associate professor at UFRN.

Our lab implements genetic tools for studying and modulating neuronal activity. We use opto- and chemogenetic strategies together with cre-lox mice strains and/or viral constructs to target and control unique cell populations of the auditory system. We use in vitro electrophysiology to study ion currents related to altered neuronal activity. This data is complimentary to in vivo models using unit recordings (acute/chronic multichannel electrodes) to quantify neuronal activity, both sensory driven and spontaneous. We also record auditory event-related potentials to correlate sensory gating to regulation of neuronal activity. For tinnitus research we implement auditory brainstem responses to define hearing threshold of mice, noise-overexposure to induce tinnitus without hearing loss, and we use Gap prepulse inhibition of acoustic startle tests to evaluate tinnitus perception in mice.


Publications

Anders Enjin, Sharn Perry, Markus M Hilscher, Chetan Nagaraja, Martin Larhammar, Henrik Gezelius, Anders Eriksson, Katarina E Leão and Klas Kullander. Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit. J. Neurosci ; 10.1523/JNEUROSCI.0949-16.2017 .
Full Text [WEB]

Hilscher MM, Leão RN, Edwards SJ, Leão KE, Kullander K (2017) Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation. PLoS Biol 15(1): e2001392. doi:10.1371/journal.pbio.2001392
Full Text [WEB]

Hilscher MM, Leão KE, Leão RN. Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit. Front Neural Circuits. 2013.
Full Text [PDF]

LEÃO, RICHARDSON N ; Mikulovic, Sanja ; LEÃO, KATARINA E ; MUNGUBA, HERMANY ; GEZELIUS, HENRIK ; ENJIN, ANDERS ; PATRA, KALICHARAN ; ERIKSSON, ANDERS ; LOEW, LESLIE M ; TORT, ADRIANO B L ; Kullander, Klas . OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nature Neuroscience (Print), v. 15, p. 1524-1530, 2012.
Full Text [WEB]

LEAO, KE ; Mikulovic, Sanja ; Le Merre, Pierre ; Tourtellotte, Warren G. ; Kullander, Klas . Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons. Molecular and Cellular Neurosciences (Print), v. 49, p. 322-332, 2012.
Full Text [WEB]

LEAO, KE ; Leão, Richardson N. ; Walmsley, Bruce. Modulation of dendritic synaptic processing in the lateral superior olive by hyperpolarization-activated currents. European Journal of Neuroscience (Print), v. 33, p. 1462-1470, 2011.
Full Text [WEB]

Leão, Katarina E. ; Leão, Richardson N. ; Deardorff, Adam S. ; Garrett, Andrew ; Fyffe, Robert ; Walmsley, Bruce. Sound stimulation modulates high-threshold K+ currents in mouse auditory brainstem neurons. European Journal of Neuroscience (Print), v. 32, p. 1658-1667, 2010.
Full Text [WEB]

Leão, Richardson N. ; Naves, Marcell M. ; Leão, Katarina E. ; Walmsley, Bruce. Altered sodium currents in auditory neurons of congenitally deaf mice. European Journal of Neuroscience (Print), v. 24, p. 1137-1146, 2006.
Full Text [WEB]

Leao, K. E. ; Leao, R. N. ; Sun, H. ; Fyffe, R. E. W. ; Walmsley, B. . Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei. Journal of Physiology (London. Print), v. 576, p. 849-864, 2006.
Full Text [WEB]

Leao, R. N. ; Sun, H. ; Svahn, K. ; Berntson, A. ; Youssoufian, M. ; Paolini, A. G. ; Fyffe, R. E. W. ; Walmsley, B. . Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness. Journal of Physiology (London. Print), v. 571, p. 563-578, 2006.
Full Text [WEB]

Leao, Richardson N. ; Svahn, Katarina ; Berntson, Amy ; Walmsley, Bruce . Hyperpolarization-activated ( I h ) currents in auditory brainstem neurons of normal and congenitally deaf mice . European Journal of Neuroscience (Print), v. 22, p. 147-157, 2005.
Full Text [WEB]


Laboratório Multiusuário de Microscopia

Click here to more

Last entries