›  Home  ›  aboutus  ›  Emelie Katarina Svahn Leão  
Emelie Katarina Svahn Leão

Emelie Katarina Svahn Leão

Associate Professor, Brain Institute - Federal University of Rio Grande do Norte (UFRN)
Laboratory: Hearing and neuronal activity lab
Lattes: http://lattes.cnpq.br/1279823352935722
E-mail: katarina.leao@neuro.ufrn.br
Areas of interest: The pathological perception of sounds in the auditory system (in relation to tinnitus and psychosis)

Master degree in Pharmaceutical Bioscience from University of Gothenburg, Sweden, 2004. She obtained a PhD in Neuroscience at the National University of Australia, Canberra, Australia, 2008, studying plasticity in the auditory system of mice. Returning to Sweden for a postdoc at Uppsala University she took part in several projects using transgenic animals, using electrophysiology and immunohistochemistry. In 2012 she became associate professor at UFRN.


Research interests: Identify genetic profiles of neurons of the auditory system (cochlear nucleus, lateral lemniscus, inferior colliculus, medial geniculate body and auditory cortex); Modulate excitability and control activity of homogeneous groups of auditory neurons using optogenetics and chemogenetics; Supress tinnitus perception in a behavioural model (the gap pre-pulse inhibition of the acoustic startle reflex).

Methodology: Transgenic animals; Viral vectors; Auditory brainstem response; Behavioural test (GPIAS; Gap pre-pulse inhibition of the acoustic startle reflex); Electrophysiology (Unit records; Whole-cell patch clamp); Immunohistochemistry; Confocal microscopy.


Publications

Anders Enjin, Sharn Perry, Markus M Hilscher, Chetan Nagaraja, Martin Larhammar, Henrik Gezelius, Anders Eriksson, Katarina E Leão and Klas Kullander. Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit. J. Neurosci ; 10.1523/JNEUROSCI.0949-16.2017 .
Full Text [WEB]

Hilscher MM, Leão RN, Edwards SJ, Leão KE, Kullander K (2017) Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation. PLoS Biol 15(1): e2001392. doi:10.1371/journal.pbio.2001392
Full Text [WEB]

Hilscher MM, Leão KE, Leão RN. Synchronization through nonreciprocal connections in a hybrid hippocampus microcircuit. Front Neural Circuits. 2013.
Full Text [PDF]

LEÃO, RICHARDSON N ; Mikulovic, Sanja ; LEÃO, KATARINA E ; MUNGUBA, HERMANY ; GEZELIUS, HENRIK ; ENJIN, ANDERS ; PATRA, KALICHARAN ; ERIKSSON, ANDERS ; LOEW, LESLIE M ; TORT, ADRIANO B L ; Kullander, Klas . OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nature Neuroscience (Print), v. 15, p. 1524-1530, 2012.
Full Text [WEB]

LEAO, KE ; Mikulovic, Sanja ; Le Merre, Pierre ; Tourtellotte, Warren G. ; Kullander, Klas . Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons. Molecular and Cellular Neurosciences (Print), v. 49, p. 322-332, 2012.
Full Text [WEB]

LEAO, KE ; Leão, Richardson N. ; Walmsley, Bruce. Modulation of dendritic synaptic processing in the lateral superior olive by hyperpolarization-activated currents. European Journal of Neuroscience (Print), v. 33, p. 1462-1470, 2011.
Full Text [WEB]

Leão, Katarina E. ; Leão, Richardson N. ; Deardorff, Adam S. ; Garrett, Andrew ; Fyffe, Robert ; Walmsley, Bruce. Sound stimulation modulates high-threshold K+ currents in mouse auditory brainstem neurons. European Journal of Neuroscience (Print), v. 32, p. 1658-1667, 2010.
Full Text [WEB]

Leao, K. E. ; Leao, R. N. ; Sun, H. ; Fyffe, R. E. W. ; Walmsley, B. . Hyperpolarization-activated currents are differentially expressed in mice brainstem auditory nuclei. Journal of Physiology (London. Print), v. 576, p. 849-864, 2006.
Full Text [WEB]

Leão, Richardson N. ; Naves, Marcell M. ; Leão, Katarina E. ; Walmsley, Bruce. Altered sodium currents in auditory neurons of congenitally deaf mice. European Journal of Neuroscience (Print), v. 24, p. 1137-1146, 2006.
Full Text [WEB]

Leao, R. N. ; Sun, H. ; Svahn, K. ; Berntson, A. ; Youssoufian, M. ; Paolini, A. G. ; Fyffe, R. E. W. ; Walmsley, B. . Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness. Journal of Physiology (London. Print), v. 571, p. 563-578, 2006.
Full Text [WEB]

Leao, Richardson N. ; Svahn, Katarina ; Berntson, Amy ; Walmsley, Bruce . Hyperpolarization-activated ( I h ) currents in auditory brainstem neurons of normal and congenitally deaf mice . European Journal of Neuroscience (Print), v. 22, p. 147-157, 2005.
Full Text [WEB]


Last entries