"Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using Sox2, Ascl1, and Neurog2"

Here, we show that the expression of the transcription factor SRY (sex determining region Y)-box 2 (Sox2), Ascl1 or Neurog2 is sufficient to lineage-convert a small fraction of human umbilical cord mesenchymal stem cells (hUCMSCs) into iNs.

Publications

Subtle Alterations in Spatial Memory Induced by Amyloid Peptides Infusion in Rats"
Jan 30, 2018

In the present study, we evaluated the effects of a low-dose 15-day long treatment with Ab peptides on spatial and non-spatial strategies of rats tested in the Barnes maze. Ab peptides (0.5 mL/site/day; 30 pmoL solution of Ab1–40:Ab1–42 10:1) or saline were bilaterally infused into the CA1 (on the first treatment day) and intraventricularly (on the following 15 days) in 6-month-old Wistar male rats."

Specifc Phospholipids Regulate the Acquisition of Neuronal and Astroglial Identities in Post-Mitotic Cells"
Jan 17, 2018

Embryonic stem cell diferentiation in specifc cell lineages is a major issue in cell biology, and particularly, in regenerative medicine. Neural stem cells (NSCs) have the potential for self-renewal and diferentiation into neurons, astrocytes and oligodendrocytes."

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations"
Jan 17, 2018

Understanding the mechanisms that control critical biological events of neural cell populations, such as proliferation, differentiation, or cell fate decisions, will be crucial to design therapeutic strategies for many diseases affecting the nervous system."

The interpretation of dream meaning: Resolving ambiguity using Latent Semantic Analysis in a small corpus of text"
Nov 07, 2017

Computer-based dreams content analysis relies on word frequencies within predefined categories in order to identify different elements in text."

The language of geometry: Fast comprehension of geometrical primitives and rules in human adults and preschoolers"
Oct 24, 2017

Here, we ask whether a “geometrical language” with recursive embedding also underlies the human ability to encode sequences of spatial locations. "

Direct Reprogramming of Adult Human Somatic Stem Cells Into Functional Neurons Using Sox2, Ascl1, and Neurog2"
Jun 12, 2018

Here, we show that the expression of the transcription factor SRY (sex determining region Y)-box 2 (Sox2), Ascl1 or Neurog2 is sufficient to lineage-convert a small fraction of human umbilical cord mesenchymal stem cells (hUCMSCs) into iNs."

Respiration-Entrained Brain Rhythms Are Global but Often Overlooked"
Apr 20, 2018

We summarize recent evidence showing that nasal respiration entrains oscillations at the same frequency as breathing in several regions of the rodent brain."

Callosal Influence on Visual Receptive Fields Has an Ocular, an Orientation-and Direction Bias"
Apr 17, 2018

One leading hypothesis on the nature of visual callosal connections (CC) is that they replicate features of intrahemispheric lateral connections. However, CC act also in the central part of the binocular visual field. "

Motion contrast in primary visual cortex: a direct comparison of single neuron and population encoding"
Feb 15, 2018

We analyzed firing rates and phase-locking to low-gamma frequency in single cells and neuronal assemblies. Motion contrast was reflected in all measures but in semi-independent populations."

Extracting information from the shape and spatial distribution of evoked potentials."
Jan 31, 2018

Over 90 years after its first recording, scalp electroencephalography (EEG) remains one ofthe most widely used techniques in human neuroscience research, in particular for the study of event-related potentials (ERPs)."

Events

ICe-UFRN e Delta9 realizam 3º fórum sobre maconha medicinal

Natal sedia no próximo dia 26, o 3º Fórum Delta9 – maconha, sociedade e saúde, com objetivo de abordar as implicações e benefícios da legalização e regulamentação dos derivados da cannabis. O evento acontece no Praia Mar Hotel & Convention, das 9h às 17h. As inscrições podem ser feitas pelo site www.delta9cannabis.com.br até o próximo dia 20."

Natal sedia segunda edição do Pint of Science

Festival de divulgação científica acontece nos dias 14, 15 e 16 de maio no Mormaço e no Bar 54."

Semana do Cérebro: 7° edição acontece entre 11 e 16 de março

Acampamento do MST, comunidade quilombola e espaços públicos de Natal e Serra Negra do Norte receberão oficinas e apresentações."

In The Media

Ayahuasca pode ajudar no tratamento de depressão, diz estudo

Um grupo de cientistas brasileiros realizou o primeiro ensaio randomizado com ayahuasca, controlado por placebo, em 29 pacientes com depressão e os resultados são animadores."

Sidarta Ribeiro conta experiência com psicodélicos na Trip

Neurocientista Sidarta Ribeiro revela o que viu e sentiu na sua primeira viagem lisérgica, em Goiás"

Instituto do Cérebro seleciona voluntárias para pesquisa sobre hormônios sexuais

O Projeto Endocrino-Motor, desenvolvido no laboratório de Endocrinologia Comportamental do Instituto do Cérebro da Universidade Federal do Rio Grande do Norte (ICe-UFRN), está selecionando voluntárias para participar de pesquisa que investiga como os hormônios sexuais podem afetar o cérebro. O estudo é conduzido pela doutoranda Rafaela Faustino, com orientação da neurocientista Bernardete Sousa."


Rereading the mind. Unbiased discovery of neural correlates of behavior

Click here to more

Last entries