"Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit "

Here we used the selective expression of the nicotinic cholinergic receptor alpha 2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid transporter (VIAAT) in Renshaw cells.

Publications

Thought disorder measured as random speech structure classifies negative symptoms and schizophrenia diagnosis 6 months in advance"
Apr 18, 2017

This analysis relies mostly on connectedness, a structural feature of speech that is anti-correlated with negative symptoms."

Coupled variability in primary sensory areas and the hippocampus during spontaneous activity"
Apr 10, 2017

The cerebral cortex is an anatomically divided and functionally specialized structure. It includes distinct areas, which work on different states over time. "

Physiology and assessment as low-hanging fruit for education overhaul"
Mar 31, 2017

Physiology and assessment constitute major bottlenecks of school learning among students with low socioeconomic status."

Chrna2-Martinotti Cells Synchronize Layer 5 Type A Pyramidal Cells via Rebound Excitation"
Mar 22, 2017

Chrna2-Martinotti cells participate in defined cortical circuits and can synchronize pyramidal cells in a frequency-dependent manner."

Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development"
Jan 18, 2017

Neuronal survival and morphological maturation depends on the action of the transcription factor calcium responsive element binding protein (CREB), which regulates expression of several target genes in an activity-dependent manner. "

Developmental disruption of recurrent inhibitory feedback results in compensatory adaptation in the Renshaw cell - motor neuron circuit "
Jun 05, 2017

Here we used the selective expression of the nicotinic cholinergic receptor alpha 2 (Chrna2) in mice to genetically target the vesicular inhibitory amino acid transporter (VIAAT) in Renshaw cells. "

Chronic nicotine attenuates behavioral and synaptic plasticity impairments in a streptozotocin model of Alzheimer's disease."
May 13, 2017

Brain glucose metabolism is altered in sporadic Alzheimer's disease (sAD), whose pathologies are reproduced in rodents by intracerebroventricular (icv) infusion of streptozotocin (STZ) in subdiabetogenic doses. "

Selective post-training time window for memory consolidation interference of cannabidiol into the prefrontal cortex: Reduced dopaminergic modulation and immediate gene expression in limbic circuits."
May 12, 2017

The prefrontal cortex (PFC), amygdala and hippocampus display a coordinated activity during acquisition of associative fear memories."

Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats"
May 10, 2017

Dopamine release and phase-amplitude cross-frequency coupling (CFC) have independently been implicated in prefrontal cortex (PFC) functioning."

Selective entrainment of gamma subbands by different slow network oscillations"
May 04, 2017

Respiration-induced oscillations and the theta rhythm modulate different gamma frequencies, suggesting that the brain uses different frequency channels for transferring different types of information."

Events

Instituto do Cérebro realiza 2o House Symposium

Com o tema “The Brain in a Nutshell”, o evento é gratuito e aberto à comunidade acadêmica. "

Instituto do Cérebro promove palestra sobre imunidade e processo cognitivo

A palestra é gratuita e voltada para a comunidade acadêmica, especialmente das áreas das biociências, saúde e neurociências."

Palestra de Neurobiologia

A palestra “Neurobiologia da diferenciação sexual” será ministrada pela professora Maria Bernardete Cordeiro de Sousa."

In The Media

BBC entrevista Sidarta Ribeiro e Dráulio Barros de Araújo sobre drogas psicodélicas

A reportagem mostra que 2017 é o marco do "renascimento psicodélico" na ciência."

Trabalho de pesquisadores do ICe é escolhido para a capa de revista científica internacional

A imagem da capa foi produzida pela autora do estudo Melek Chouchane e por Lorenzo Pasquini. "

Sidarta Ribeiro ministra palestra no Instituto Tomie Ohtake

A apresentação faz parte do programa de residência “Inquietudes” voltado para artistas, gestores, produtores e empreendedores. "


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